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Anti-gout Capsules on the Treatment of Gouty Arthritis and Its Mechanism

Author: YuanLiangDong
Tutor: YuZuo
School: Zunyi Medical College,
Course: Internal Medicine
Keywords: Gouty arthritis Intereukin-1β Tumor necrosis factor-a Chinese medicine Rats
CLC: R259
Type: Master's thesis
Year: 2011
Downloads: 3
Quote: 0
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Abstract


Objective:To observe and analysis anti-gout capsule effects and the machanism on acute gouty arthritis (GA) in rats.Methods:Fifty rats were randomly divided into five groups:control、model、positive controlcochicine (0.8mg/kg)、low dose anti-goutcapsule(0.3g/kg) and high dose anti-gout groups(1.2g/kg), Besides control group, the gout model was made in other groups by injected sodium urate into joint cavity, Intragastirc administration of anti-gout capsule lml/100g, Anti-gout capsule groups were given once a time for 5 days, Positive control and model group were given equal volume of water, The gait changes and joint volume were observed in rats with treatment after 5 days The abdominal aortic blood and synovial fluid were collected for determine contents of IL-1βand TNF-αby ELISA method.Results:Compared with model group, the high dose and low dose anti-gout capsule group could inhibit ankle swelling caused by uric acid sodium, and joint volume obviously decreased after the injection 2 days to 5 days, These recovery have likely control group, and improve the abnormalities of gait, The contents of IL-1βand TNF-αwere obviously higher in model group than control group in synovial fluid and serum, The level of TNF-ain serum and the contents of IL-1βand TNF-a in synovial fluid were lower than modle group.Conclusion:Anti-gout capsule has significantly anti- inflammation and down swelling of joint in GA rats, The mechanism may be have related to decrase the joint inflammation damage cause by IL-1βpand TNF-α.

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