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Detection Sensitivity and Optimization Techniques for Nuclear Magnetic Resonance Spectrometer

Author: ZuoXiaoJun
Tutor: ChenZhong
School: Xiamen University
Course: Instrumentation Engineering
Keywords: Nuclear Magnetic Resonance(NMR) Detection Sensitivity Optimization Technique
CLC: R445.2
Type: Master's thesis
Year: 2008
Downloads: 207
Quote: 0
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Abstract


As it is known to all, nuclear magnetic resonance (NMR) has been applied widely to various field that the detailed information about molecular structure, dynamics, and whole human body, brain function can be obtained, and NMR instruments have become one of important equipment to solve major scientific, economic, environmental and social issues. In this paper, the detection sensitivity and related optimization techniques for high-resolution NMR spectrometer were discussed by combine with the development of 500MHz spectrometer from both theoretical and experimental analysis.1. First, the basic structure of modern nuclear magnetic resonance spectrometer was brief and introduced with the detection sensitivity of the relevant technical parameters, the definition of sensitivity and measurement, 90°pulse width, and the resolution of spectrum and rotary sideband, and so on.2. The effects of factors such as the magnetic field strength, concentration and sample size, the probe quality factor, noise, RF field strength, relaxation etc on the detection sensitivity of high-resolution NMR spectrometer were analyzed in theory. It is clear that to enhance the signal and reduce noise is the two main aspects of improving the sensitivity. High magnetic field intensity, high-quality factor and fill factor of the probe, low-noise electronic circuits is the key to enhance signal to noise ratio.3. From the perspective of spectrometer development, the ways and measures to improve the sensitivity were explored and the structure of the design of the 500MHz indirect detection probe, low-noise preamplifier and the development of radio-frequency system, and other key technical issues was focused on.4. Finally, in combination with practical application and actual operation of magnetic resonance spectrometer, the experimental techniques to improve spectrometer performance including increase of the magnetic field uniformity and stability, the best detection sensitivity of the probe, optimization experimental parameters were summarized. Particularly, the automatic three-dimensional gradient Shimming technology and 90°pulse width measurement were focused on.

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CLC: > Medicine, health > Clinical > Diagnostics > Diagnostic Imaging > Magnetic resonance imaging
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