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The Effect of VEGF、p53、CD34 and c-fos in Tumorous Invasion and Metastasis of Rectal Carcinoma

Author: SunJiaSheng
Tutor: PanYunLong
School: Jinan University
Course: Surgery
Keywords: rectal cancinomoa immunohistochemistry VEGF p53 CD34 c-fos invasion lymphatic metastasis
CLC: R735.3
Type: Master's thesis
Year: 2009
Downloads: 60
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Abstract


Objective:To study the expression of vascular endothelial growth factor VEGF、p53、CD34 and c-fos in rectal carcinoma tissue,analyze their relationships and the correlation between clinical and pathological data.To explore the correlation between the combined expression of VEGF、p53、CD34 and c-fos and differenced depth of invasion and lymphatic metastasis of rectal carcinoma cells,as well as to find out the effective and objective parameters for anticipation of rectal carcinoma.Method:We test the expression of VEGF、p53、CD34 and c-fos in the tissue of 80 rectal carcinoma and 20 normal tissue by the side of rectal carcinoma with immunohistochemistry S-P means,and combine the clinical,pathological parameters, depth of invasion and conditions of lymphatic metastasis to make statistical analysis and comparison.Result:1.There is a correlation between the positive expression of VEGF、p53、CD34 and c-fos proteins in rectal carcinoma,depth of invasion,TNM and lymphatic metastasis.(P＜0.05).2.The combined expression of VEGF、p53、CD34 and c-fos in the rectal carcinomoa can make it develop to the chorion invasion,worse TNM and lymphatic metastasis3.There is positive correlation between the expression of VEGF、p53、CD34 and c-fos in the rectal cancinomoa(P＜0.05,r_s＞0).4.The single factoe of VEGF、p53、CD34 and c-fos is not the independent dangerous factor for rectal cancinomoa’s chorion invasion,but c-fos is the independent dangerous factor for rectal cancinomoa’s lymphatic metastasis.Conclusion:The expression of VEGF、p53、CD34 and c-fos is higher in the rectal cancinoma with chorion invasion and lymphatic metastasis,and the cooperation expression of them makes the tumour’s chorion invasion and lymphatic metastasis more easly.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms
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