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Liver is one of the most significant organs, with the largest volume and complicated functions. And what is more, it is also be the center which is in charge of participating in metabolism of carbohydrate, lipids and protein. In addition, it has many functions, such as detoxication, hematopoiesis, blood clotting and immunologic barrier. As a digestive gland, it leads excretion of bile, as well as synthesis of many bioactive materials. In Chinese Medicine, liver has the duty of body actions and virus defense, all of these above have been powerfully proved that the healthy of liver is vital to human bodies.Liver diseases are common in China and are liable to be taken place, especially viral hepatitis. Parts of its patients will change into hepatic cirrhosis, even to hepatic cancer, which bring mass of disasters to them. Pathological changes of liver also can be caused by virus, parasitic infection, diseases poisoning and many other factors, which accrete connective tissue in liver. Thus, it is urgent to do research in pathogenesis and medicine therapies of liver disease all around the world.Hepatic fibrosis is a character of prophase cirrhosis, and the common pathology reform of chronic hepatitis to cirrhosis. It performs unbalance of extra-cellular matrix (ECM) synthesis and decomposition, which leads to deposit of ECM, and to cause fibrous connective tissue sediment abnormally in liver. Hepatic fibrosis, as an initiative and convertible procedure of hepatic injury, its pathology features are as follows, large amount of collagen fibers I and III forms in headers and lobules of liver, which leads fibers tuberosity and destroy the normal structure, which eventually leads to cirrhosis, degeneration of liver, and sometimes to be cancer. If the disease has existed without control for a long time, it will be aggravated and hepatic lobule and vessels will be rebuilt. Distances, form to pseudolobule, will appear during the sections of veins and headers, and then become to irreversible cirrhosis. In one word, hampering and converting hepatic fibrosis is one of important strategies to cure each kind of chronic hepatitis. At present, there is lack of efficient anti-fibrosis medicines without obvious side effects, and further more, majority medicines always affect on single joint or with one target, this phenomenon impede the entire process of therapy. On the other hand, Chinese Medicine Recipes have many virtues as little cost, high security and different target points. As a result, lots of patients turn to Chinese Medicine Recipes.The Chinese Medicine Recipe ZGG using in our research is devised by a famous Chinese physician with high reputation in Jilin Province, which is composed of Panax Ginseng C.A.Meyer, Turtles Gelatin, Radix Paeoniae Rubra Polygonummultiflorum Thunb, and Rehmannia glutinosa as basis. And what is more, it has the function of activating blood circulation, soften lump, loosen knot and tonifying energy. ZGG has already manifested good clinical effects on liver protection in cirrhosis with lower albumin. The former pharmacological research also proved that ZGG has effects of protecting liver, promoting albumin and reversing the cirrhosis forming.With the characters of Chinese Medicine Recipes, such as unavoidable complication and uncertain active parts of components as well as many difficulties to control its quality, are resulted in the cut of medical effects and high cost of manufacture, all of these hamper the widely use and modern developments of Chinese Medicine Recipes. In order to control the qualities and quantities of Chinese Medicine Recipes, it is necessary to minimize the mutual effects of components in recipes, without therapeutic influences. It is the tendency of research on less components recipes.Thus, we extract the main basis of ZGG–Panax Ginseng adds Turtles Gelatin to SGP (less components recipe).Through the experimental hepatic fibrosis rats established by hypodermic injection CCl4 and arachis oil, we intend to observe the index of protein level, hepatic function, oxidative damage and tissue collagen, compared with ZGG, in order to provide effective and feasible pharmacodynamic evidences in curing hepatic fibrosis and low albumin diseases with Chinese Medicine Recipes.The results are as follows. After introgastric-infused for one month, SGP 4、8g/kg can enhance body constitution , reduce liver coefficient, and notable increase albumin (ALB) , A/G and lower globulin (GLO). Furthermore, it markedly decrease the level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin (BIL), and increase cholinesterase (CHE) of serum; Moreover, it remarkably downsize the content of malonaldehyde (MDA)and upsize the activity of superoxide dismutase (SOD) and glutathione-S transferase (GSH-ST) in liver .At the same time, it also leads to the drop of hydroxyproline (Hyp) in liver. As the results above, we can demonstrate that SGP has the same effects in enhancing and improving liver situations to ZGG. Thus, SGP may probably affect procedures of synthesis of protein in liver, especially synthesis of albumin, adjustment of olig-albuminemia and inversion of A/G, as well as prevention of collagen abnormally sediment. On the other hand, it maybe also through the mechanism of reducing lipid oxidation, cleaning free radicals and reducing necrosis to resist hepatic fibrosis.In the end, we can draw a conclusion, despite of less components of SGP, there are identifiable effects to ZGG in conquering hepatic fibrosis. In addition, SGP can striking raise ALB of serum, which means SGP has the promising potential to apply and develop.
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