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Effect of Breviscapin on INa Channel Current in Isolated Ventricular Myocytes of Rats

Author: TangChengJing
Tutor: LiZiCheng
School: Jinan University
Course: Department of Cardiology
Keywords: Breviscapine Cardiomyocytes sodium channel
CLC: R285.5
Type: Master's thesis
Year: 2009
Downloads: 59
Quote: 0
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Abstract


Objective:The effects of breviscapine on INa channel in isolated ventricular myocytes of rats were determined. The mechanism of breviscapine at the ionic channel level was explored. Methods:Single ventricular myocytes of rats were isolated by enzymatic dissociation. The whole-cell patch-clamp recording technique was used to record the change of INa channel current influenced by breviscapine. Results:（1） Breviscapine decreased the INa channel current in a dose-dependent andvoltage-dependent manner in ventricular myocytes of rats.（2） The current-voltage curve was significantly decreased. Breviscapin at concentrations of 1, 3, 30, 100 mg·L-1 respectively decreased INa current density （7.98±0.6） %, （37.73±2.31） %, （65.58%±2.9） % and （88.09±5.6） %. INa was inhibited in a voltage-dependent manner, showing a significant attenuating effect at test potentials from -30 mV to 0.（3） The INa inactivation curve was shifted to left and the activation curve was shifted to right.（4） Breviscapine could make the recovery curve slower.Conclusions:Breviscapine concentration-dependently decreased INa channel current in rat ventricular myocytes.

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