Dissertation > Excellent graduate degree dissertation topics show

Resuscitative Time and Vitamin C on Epithelial Cell Apoptosis of Skin Hair Follicle Partial Thickness Burn in Rats

Author: ChaTianJian
Tutor: MaShaoLin
School: Xinjiang Medical University
Course: Burn Surgery
Keywords: Resuscitative Vitamin C Apoptosis
CLC: R644
Type: Master's thesis
Year: 2011
Downloads: 7
Quote: 0
Read: Download Dissertation

Abstract


Objective: To study of the resuscitative time and of Vitamin C burn skin hair follicle epithelial cell apoptosis, and to explore its mechanisms in rats. Methods: Fifty Wistar male rats, weighing (200±20g), were remove back hair with 10% sodium sulfide, were randomly divided into five groups, 1) sham group; 2) in a timely manner the resuscitative group; 3) and timely resuscitative of Vitamin C group; 4) delayed resuscitation group; 5) vitamin C delayed resuscitation group. Detect the skin and Serum MPO, SOD, NOS activity and NO, MDA content changes, and rat skin morphological changes observed by light microscopy, immunohistochemistry, Bax/Bcl-2 staining and electron microscopy after 18h. Results: 1) Timely resuscitative and use of Vitamin C can reduce the serum and skin MPO activity; 2) Timely resuscitative and use of Vitamin C can reduce the serum and skin tissue MDA, increased SOD activity in serum and skin tissue; 3) Delayed resuscitative and use of Vitamin C can reduce the NO content in serum and skin; 4) Delayed resuscitative and use of Vitamin C can reduce the serum and skin TNOS activity and iNOS activity; 5) Timely resuscitative and use of Vitamin C can be reduce the expression of Bax and improve skin Bcl-2 expression. Conclusion: Timely resuscitative and joint use of large doses of Vitamin C on the skin’s protective effect may inhibiting neutrophil aggregation, inhibition of lipid peroxidation and inhibition of skin cell apoptosis.

Related Dissertations

  1. The Study on Cryopreservation and Mechanism of Freezing Injury on the Spermatozoa of Coelomactra Antiquate,S968.3
  2. The Anti-tumor Effect of CADPE and Inducing Apoptosis in Human Gastric Cancer Cells,R735.2
  3. Cloth and β- elemene combined administration of anti-tumor effect and mechanism of celecoxib,R96
  4. TRAIL in the regulation of tumor invasion CD4 ~ CD25 ~ Treg,R730.2
  5. The Study of Lead Exposure on Cyprinus Carpio Ovary Epithelial Cells,X174
  6. Studies on the Formation and Control of Volatile N-Nitrosamines in Dry-Cured Meat,TS251.51
  7. Effects of Diclazuril on G3PDH in Second-generation Merozoites of Eimeria Tenella,S858.31
  8. The Effects and Preliminary Study of PCV2 on Ca2+ Signal in Lymphocytes of Piglets,S858.28
  9. Effects of Angiogenic Factor on Follicular Angiogenesis and Development in Sexual Maturity Mice,S852.2
  10. Expression of β-Catenin in Pig’s Ovary and the Effect of β-Catenin on Porcine Granulosa Cells Apotosis and Steroidogenesis Related Enzyme,S828
  11. Induced Combination Apoptosis by FB1 and AFB1 in Vero Cell,S856.9
  12. The Apoptosis Mechanism Induced by Aflatoxin B1 and Deoxynivalenol in Primary Hepatocyte of Cyprinus Carpio,S856.9
  13. Effects of BMPR-IB Gene Silencing by Small Interfering RNA on Apoptosis of Porcine Pollicular Granulosa Cells and Ecpression of BMP Pathy-Way-Ralted Genes,S828
  14. The Effects of Don on Proliferation, Differentiation, and Apoptosis of Chondrocytes in Chicken,S858.31
  15. The Effect of Foxol on Apoptosis of Mouse Granule Cells,S865.13
  16. Study of Melittin on Tumor Inhibition and Part of Mechanism of Human Hepatocellular Carcinoma HepG-2 Xenograft in Nude Mice,R735.7
  17. The Protective Effect of Rat Myocardial Ischemia/reperfusion Injury Following Bone Marrow Mesenchymal Stem Cell Pretransplantation for 1 Week,R542.22
  18. The Influence of Early Intervention of Vitamina Combined with Mycobacterium Bovis Bacillus Calmette-Guerin on Lung CD11C+ and Anti-OVA Special IgE Expression in Adult SD Mice Asthma Model,R562.25
  19. The Influence in Different Route of Medication with Vitamin A on CD4~+CD25~+ Regulatory T Cell and Cell Factor of IL-4、 IFN-γ in a Rat Persistent Asthma Model,R562.25
  20. Effects of Vitamin A and Montelukast on Airway Inflammatory Cells and Th1/Th2 Balance in Mouse Model of Asthma,R725.6
  21. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8

CLC: > Medicine, health > Surgery > Traumatology > Burns and scalds ( burns )
© 2012 www.DissertationTopic.Net  Mobile