|
Background:Cervical cancer (cervical cancer) is the most common gynecologic cancer in China, China each year about 131,500 new cases, accounting for the total world incidence of 1 / 3. In recent years, large research and experiments show that the bright, high-risk HPV (human papilloma virus, HPV) persistent infection is a necessary condition for cervical cancer and the major risk factors. HPV persistence, is constantly repeated evolution of cervical lesions in the molecular markers. Cervical cytology, high-risk HPV detection combined with colposcopic biopsy of cervical lesions and cervical cancer is the most effective way of screening. Reported in the literature for high-risk HPV testing in equivocal cytology of atypical squamous epithelium (atypical squamous cells undetermined significance ASC-US) has diverted some 35 years of age reported in the literature for low-grade squamous intraepithelial lesion (low-grade squamous intraepithelial lesions LSIL) with traffic diversion. Cervical lesions as a diversion "factor "need to have the following characteristics: (1)It is closely related with the occurrence of cervical lesions and persistent. (2) It for the stage of cervical lesions in 50% infection rate is the best time. (3) It has an accurate, efficient and convenient means of detection and easy to detect.Purpose:Screening of cervical lesions to cervical cytology in patients with mildly abnormal not to over-treatment, do not do unnecessary tests and waste of resources. By retrospective analysis, research high-risk HPV detection in cytology ASC-US and LSIL in traffic diversion.Method:Select October 20, 2009 to March 31, 2011 at the First Affiliated Hospital of Dalian Medical University, Dalian Central Hospital of Obstetrics and Gynecology clinics and outpatient cervical cytology (TCT) in patients with 9036 cases, all the first elected Second line of cytology and HPV testing high-risk cases of normal and abnormal results of 2165 cases, and to elect one of colposcopy biopsy cases; also elected abnormal cytology, did not check high-risk HPV, colposcopy under the direct 56 cases of biopsy cases, a total of 2221 cases, the analysis of the results of these tests, draw conclusions.Results:ASC-US patients with 408 cases, 251 high-risk HPV testing routine, positive in 121 cases, the positive rate was 48.2%. ASC-US HPV positive in 70 patients with routine colposcopic biopsy, 21 cases of CIN2 + detected; HPV-negative biopsy in 31 cases, detected in patients with CIN2 + 1; not check for HPV patients, 26 were biopsy CIN2 + detected 7 patients. In patients with ASC-US HPV detection sensitivity was 95.5%, specificity was 38.0%, positive predictive value of 30%, negative predictive value of 100%, theχ2 test, P <0.05, statistically significant. 123 cases of patients with LSIL, the Senate review of 73 cases, 65 cases positive, the positive rate of 89.0%.Conclusion:High-risk HPV testing in ASC-US in traffic diversion. In the LSIL patients, because high-risk HPV test positive rate was 89.0%, and concentrated in 35 to 45 years of age, patients over the age of 35 can not play streaming effect; for the 45-59 age group in patients with LSIL, The positive detection rate of high-risk HPV was 80%, the infection rate has not decreased significantly. Shunt significance not evident.
|