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Acute Leukemia Bone Marrow Cells in Remission’s Patients with CD Antigen Expression and the Affect of Proliferation by Modified Preparation of Qing Hao Bie Jia Soup

Author: XieWenFeng
Tutor: ZhangDan
School: Guangzhou University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: acute leukemia remission modified preparation of Qing Hao Bie Jia Soup CD antigen cell cycle
CLC: R273
Type: Master's thesis
Year: 2009
Downloads: 52
Quote: 0
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Abstract


Clinical ResearchObjective:Qing Hao Bie Jia Tang Soup after remission of acute leukemia inclinical use,to observe its post-remission bone marrow cells of different CD antigen composition and Proliferation,to further explore Qudu Fuzheng through evil on the treatment of minimal residual leukemia effect and possible mechanism of action.Methods:Patients with AL-CR qualified 22 cases,according to a randomized crossover controlled trial methods were divided into two groups:A groupthe first traditional Chinese medicine plus chemotherapy after chemotherapy alone group,B group:after the first chemotherapy alone group of Chinese medicine plus chemotherapy.Residual effect of drugs before and after each period of four weeks to eliminate.Generated the observation group(medicine plus chemotherapy group) 22 cases,the control group(chemotherapy alone group) 22 cases.Control group:conventional chemotherapy by the consolidation of maintenance therapy(ANLL with DA or MA or HA program,ALL or VDLP program with VDP) for chemotherapy,such as infection,bleeding,etc.,according to conventional anti-infective treatment and hemostasis.Observer Group:the principles of traditional Chinese and western medicine treatment with the control group.At the same time to consolidate the maintenance of oral chemotherapy modified preparation of Qing Hao Bie Jia Soup.Modified preparation of Qing Hao Bie Jia Soup,dividing twice a day,continuing for 4 weeks.Two groups of patients were collected before treatment,treatment of bone marrow after 4 weeks organizations,to conduct experiments to observe. Detected by flow cytometry before and after treatment of bone marrow cells in patients with CD3/CD19,CD13/CD14,CD33/CD34 expression,before and after bone marrow cell cycle phase of the expression and observation of patients with symptoms before and after treatment to improve the situation.The results:AML-CR compared the two groups after treatment,CD13(%),CD14(%),CD33 (%) no significant difference(P>0.05);naive cells(%),CD34(%) are different(P<0.05).Bone marrow cell cycle:thetwo groups after treatment G0/G1(%) decreased significantly than that before treatment,G2/M(%) increased significantly,the difference was significant(P≤0.01);S(%),PI (%),SPF(%) increase over pre-treatment(P<0.05).The observation group than in the control group after treatment G0/G1(%) decreased more(P<0.05),G2 /M(%),PI(%) increased more than the control group(P<0.05).Symptoms to improve the situation:efficacy of the two groups before and after treatment compared with modified preparation of Qing Hao Bie Jia Soup Group insomnia dream,dry mouth,sweating,constipation,Vomiting and poor appetite, mamillata,less moss,pulse breakdown than the chemotherapy alone group have different symptoms improved(P<0.05);for the righteousness of the symptoms of weakness,such as symptoms of dizziness,fatigue,gas lazy words, significant differences(P≤0.01).Conclusion:The Modified Decoction of Artemisia Biejia AML-CR patients with CD34(%) to reduce the role,which prompted Qing Hao Bie Jia Tang Soup may have to reduce the residual leukemia cells to chemotherapeutic drug resistance,to reduce the recurrence of the opportunity,should the prognosis of patients with better prognosis.In bone marrow effects of cell cycle,Qing Hao Bie Jia Tang Soup to reduce the percentage of G0/G1 phase cells to increase the S,G2/M phase cells the ratio of the overall increase of the cell cycle in S + G2M phase ratio of speeding up the bone marrow cells in DNA synthesis and mitotic cells to enhance vitality,reduce the overall cell cycle time,reduce the number of blasts in peripheral blood abnormalities,this mechanism may occur:1. modified preparation of Qing Hao Bie Jia Soup help kill residual leukemia tumor cells,reduce leukemia cells to DNAdamage;2.to speed up the high-level damage to cell inactivation and re-use;3.to speed up the low-level damage to cell DNA repair and so on.modified preparation of Qing Hao Bie Jia Soup righteousness in helping patients to improve the symptoms of particular symptoms effects than chemotherapy alone group highlighted,modified preparation of Qing Hao Bie Jia Soup in the treatment of MRD has its unique advantages,should be to improve the quality of life in patients with more a more in-depth research to play the whole concept of Chinese medicine andsyndromedifferentiation characteristics of the disease.

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