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The Research on the Therapeutic Effect of Microwave Ablation (MA) Combined with Injection of 5-fluorourac in Mice Bearing CT26 Colon Carcinoma Xenogrsfts

Author: LinHai
Tutor: WangYunHai
School: Xinjiang Medical University
Course: Surgery
Keywords: Microwave ablation 5 - fluorouracil Colon cancer In vivo studies
CLC: R735.35
Type: Master's thesis
Year: 2011
Downloads: 4
Quote: 0
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Abstract


Objective: To study the therapeutic effect of microwave ablation(MA)combined with injection of 5-fluorourac (5-FU) in mice bearing transplanted colon carcinoma. Methods: A Balb/c mice model inoculated with CT26 cells was established. There are four groups:group with PBS injection, group with MA, group with injection of 5-FU and group with MA combined with injection of 5-FU. The tumor volume changes; The duration and living conditions of Balb/c mice were observed; Peripheral serum levels of TNF alpha, IL-2, IL-12 and IFN-gamma were detected by ELISA. Results: tumor sizes showed that tumor treated with MA plus injection of 5-FU [(0.11+0.03)d ]significantly decreased compared with the other three groups (P<0.05). Peripheral serum levels of TNF alpha(180.3±35.9)pg/mL, IL-2 (72.5±6.8) pg/mL, IL-12 (302.3±69.6) pg/mL, IFN-gamma (68.4±8.2) pg/mL in combination therapy group were significantly higher than those in the other three groups (P<0.01). Conclusion: MA combined with 5-FU can improve anti-tumor effect by strengthening immunological FU nction and reducing local recurrences.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colon tumor
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