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Zedoary Yellow on Rectal Cancer Cells in Vitro

Author: WangZuoYuan
Tutor: LiTianWang
School: Hubei College of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: The Curcuma yellow anticancer party Human cancer Colo320 cells Proliferation Apoptosis
CLC: R735.37
Type: Master's thesis
Year: 2009
Downloads: 40
Quote: 0
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Abstract


Objective: To investigate the to Curcuma yellow anticancer square in vitro Colo320 cell proliferation , apoptosis , biological basis to clear the treatment of rectal cancer the Curcuma yellow anticancer square , new theoretical basis and source of drugs for the prevention and treatment of rectal cancer . Method : 40% , 20% , 10% , 5% , 2.5% , 1.25% six concentration Curcuma yellow anticancer parties in vitro dry Colo320 cells , the control and without serum group . Methylthiazole MTT assay and growth curve determination of the impact of different concentrations the the Curcuma yellow anticancer square Colo320 cell proliferation . Flow cytometry was used to detect different concentrations the the Curcuma yellow anticancer square Colo320 cell cycle and apoptosis rate , compared with the control group apoptosis rate to display the Curcuma yellow the anticancer party role between the apoptosis rate relationship. Results: 1. Different concentrations of the Curcuma yellow the anticancer party role Colo320 cells after 24 h by the MTT assay , Colo320 cell proliferation inhibition rate compared with control group were significantly ( P <0.01 ) , of which 10% Curcuma yellow anti-cancer side effects best Colo320 cell proliferation strongest inhibition ; , followed by 5% of Curcuma yellow anticancer party ; minimum of 1.25% the Curcuma yellow of anticancer square of Colo320 cell proliferation inhibition rate . 2 different concentrations of the Curcuma yellow the anticancer party role Colo320 cells after 48h , compared with the control group , the cell cycle distribution changed significantly , the performance of the S phase and M / Gz cells were decreased , G 0 / G 1 phase and G 1 / increase in the proportion of S - phase cells , apoptosis rate increased significantly . 3 different concentrations of the Curcuma yellow the anticancer party role Colo320 cells after 48h , there have been varying degrees of subdiploid peak , compared to the control group cells early withered rate was significantly increased , with a significant difference ( P <0.01 ) 20% Curcuma yellow anti-cancer side effects best rate of 1.25% of Curcuma yellow anticancer square Colo320 apoptosis minimum. Conclusion: Curcuma Yellow anticancer party can affect human rectal cancer Colo320 cells lifecycle inhibited proliferation and induced and induce apoptosis , so as to achieve the anti-tumor effect .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Rectal cancer
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