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The Effect of Electricity-acupuncture for the AD Model Rats on the Cholinergic System and the Apoptosis in Brain Cell

Author: WangLuShan
Tutor: ZhouLiSha
School: Hubei College of Traditional Chinese Medicine
Course: Acupuncture and Massage
Keywords: Electro-acupuncture AD model Acetylcholine Choline acetyltransferase Acetylcholinesterase Brain Cell Apoptosis
CLC: R245
Type: Master's thesis
Year: 2009
Downloads: 121
Quote: 0
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Abstract


Objective of Aβ Meynert basal ganglia 1-40 intracerebral injection establish AD model , observation of electro-acupuncture treatment of AD rat model of acetylcholine , choline acetyl transferase , acetylcholinesterase , neuronal apoptosis as well as learning and memory abilities , and to explore the mechanism of acupuncture treatment for AD , AD acupuncture treatment to provide experimental basis . Methods 40 healthy SD rats were randomly divided into normal group, sham operation group , model group and EA group . Using the bilateral basal nucleus of Meynert Trace injection cohesion state Aβ 1-40 AD rat model . Application alkaline hydroxylamine colorimetric observe the content of AD model rat hippocampus and cortex parts Ach , choline acetyltransferase enzyme test kits and acetylcholinesterase test boxes observation AD model rat hippocampus and cortex parts of choline acetyltransferase and acetylcholinesterase activity observed by Morris water maze learning and memory abilities of AD model rats . 1 EA group compared with the model group , to escape the incubation period was significantly shorter , rats significantly higher share of the percentage of the entire swimming time in the target quadrant time , the number of times through the original platform location significantly increased ( P <0.01 ) . EA group compared with the model group , the AD model rat hippocampus and cortex parts Ach content was significantly higher (P <0.01). EA group compared with the model group , the AD model rat hippocampus and cortex parts ChAT activity was significantly higher (P <0.01). EA group compared with the model group , the AD model rat hippocampus and cortex of the AchE activity decreased significantly (P <0.01). EA group compared with the model group , the AD model rat hippocampus and cortex parts of neuronal apoptosis percentage decreased significantly (P <0.01). Conclusion EA can improve learning and memory in AD model rats . 2 EA could to increase AD model rat hippocampus and cortex parts Ach content of ChAT activity , reducing the activity of AchE . Tip EA adjustable AD rat model of cholinergic system function . 4 EA can reduce the AD model rat hippocampus and cortex parts of the percentage of neuronal apoptosis . Prompts electro-acupuncture can inhibit the AD model rat brain cells apoptosis , in a way it is possible to achieve the protective effect on brain cells by the lower of Aβ 1-40 toxicity and improve the activity of the cholinergic system .

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