Dissertation > Excellent graduate degree dissertation topics show

Antithrombotic drugs - Process Synthesis prasugrel

Author: ZhangYanQiu
Tutor: WangQuanRui；ZhangHao
School: Fudan University
Course: Chemical Engineering
Keywords: Prasugrel Anti-platelet aggregation α-cyclopropylcarbonyl-2-fluoro-benzyl bromide 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-ol Hydrochloride synthesis
CLC: TQ463
Type: Master's thesis
Year: 2011
Downloads: 293
Quote: 0
Read: Download Dissertation

Abstract


Prasugrel, a new generation of oral anti-platelet aggregation drugs which was co-developed by Lilly and Sankyo, has the merits of high oral bioavailability, instant effect and loading doses free when using in the treatment of atherosclerotic disease and acute coronary syndrome.The present thesis firstly reviewed the existing synthetic routes and reaction conditions of Prasugrel. Then we designed a simple and convenient synthetic route using inexpensive and facile starting materials and reagents in consideration of industrial production. Two key steps of the route were modified. The first was one-pot synthesis of Prasugrel and the other was the synthesis of 2-bromo-l-cyclopropyl-2-(2-fluorophenyl)ethanone with a new method. Our investigation suggested that the modification of the synthetic route provide several advantages, including high overall-yield (yield was improved 14.6% to 19.7%), easy-work up, and avoiding the use of chromatography for purification.

Related Dissertations

  1. Studies on the Synthesis and Technology of Dipentaerythritol and Its Derivative,TQ223.164
  2. Synthesis and Characterization on Semi-Aromatic Polyamides Containing Benzoxazole Units,O633.5
  3. Hydrothermal Synthesis of Oxide Hollow Spheres,TB383.4
  4. Urothermal Synthesis, Structure and Characterization of Functional Coordination Polymers,O631.3
  5. Curing Mechanism and Properties of Fluorenyl Epoxy Resin,TQ323.5
  6. Syntheses of Novelbenzopyran Compounds Containing Fluorine and Induced Resistance to TMV,S435.72
  7. Expression of β-Catenin in Pig’s Ovary and the Effect of β-Catenin on Porcine Granulosa Cells Apotosis and Steroidogenesis Related Enzyme,S828
  8. Synthesis and Fungicidal Activity of 2-Acyloxycycloalkylsulfonamides,S482.2
  9. Synthesis and Development of Disodinum Clodronate、 Prasugrel and Pharmaceutical Intermediate,TQ463
  10. Research on the Precision Design of 3-TPS Hybrid Machine Tool,TG659
  11. Synthesis and Insecticidal Activity of Derivatives of Terpinen-4-ol and It’s Analogues,S482.3
  12. Studies on Preparations and Properties of Coordination Complexes Based on Carboxylate Linkers with Novel Aromatic/Saturated Ring Skeletons,O641.4
  13. The DAST crystal material synthesis and crystal growth,O782.1
  14. Synthesis and Properties of Photochromic Materials Based on Silole and other Diarylethene Compounds,O621.2
  15. Research on Soft Sensing Model of Methanol Synthesis Process Based on Improved Artificial Bee Colony Algorithm and LSSVM,TP274
  16. Discovery and optimization of novel FXR antagonists and inhibitors of DHODH,R917
  17. Hydrthermal Synthesis Alkaline Fluroides Nanomaterlas and Host for Lanthaide Near-Infrared Luminecent Properties,TB383.1
  18. Key Technology Research of Fruit Bagging Machinery,S224.9
  19. Synthesis and Application of Pyrazolone-containing Carboxyester Dyes,TQ613.24
  20. Synthesis of Trifloxystrobin, a Highly Effective and Safe Fungicide,TQ455.4
  21. Acoustic Emission Detection Technology in Applications of Synthetic Diamond Research,TQ164

CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug
© 2012 www.DissertationTopic.Net  Mobile