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Study on Synthesis of 2-methyl-2-phenyl-propan-1-ol

Author: WangLiDong
Tutor: JiaYunHong
School: Liaoning Medical
Course: Medicinal Chemistry
Keywords: Grignard reagent 2-methyl-2-phenyl-propan-1-ol synthesis
CLC: TQ243.4
Type: Master's thesis
Year: 2011
Downloads: 73
Quote: 0
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Abstract


Objective2-methyl-2-phenyl-propan-1-ol is an important intermedium,but now there is no appropriate synthesize technics which is economical and advantageous.The objective of this experiment is in search of the best method of Synthesis of 2-methyl-2-phenyl-propan-1-ol , choice the best reaction condition.so industrialization can reference this .Determine the strcture of them by the nuclear magnetic resonance detection.MethodsDid the exploration and investigate on synthesis process based on the synthesis of 2-methyl-2-phenyl-propan-1-ol which has been reported by literature.α,α-dimethyl benzylalcohol is synthesized by Grignard reagent which bromobenzene is originate material.SOCl2 is the chloridize reagent,we can get theα,α-dimethyl benzyl chloride fromα,α-dimethyl benzylalcohol.And 2-methyl-2-phenyl-propan-1-ol is obtained by Grignard reagent which is prepared from aa-dimethyl benzylalcohol reacted with paraformaldehyde 2-methyl-2-phenyl-propan-1-ol. Target compounds were prepared by Grignard reaction .Filter out the optimum conditions by single-factor experiments, in order to improve the synthetic yield. Simplize the reaction precess. Explore the thin-layer chromatography test conditions of target compounds.By thin-layer chromatography, liquid chromatography spectrometry, nuclear magnetic resonance NMR analysis to deter-mine the structure of the target compounds.ResultsReview and analyze the factor which is effect yield.control the yield of by-product. Optimize reaction step,supply a new synthetic route for target compound. The material is easy to get,reaction process is simple and hava a good yield. Structure was identified by the analysis and detectionConclusions2-methyl-2-phenyl-propan-1-ol is synthesized by Grignard reagent which bromobenzene is originate material.Improve the synthesis technology,provid a new ideas for the synthesis of target compounds. The structure was confirmed by 1H-NMR spectra.

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CLC: > Industrial Technology > Chemical Industry > Basic Organic Chemistry Industry > The production of aromatic compounds > Phenols, aromatic alcohols and their derivatives > Aromatic alcohols and their derivatives
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