Dissertation > Excellent graduate degree dissertation topics show

Investigation on Solvent Effect on Enthalpic Pairwise Interaction of Chiral Diols and Amino Acids

Author: GuoAiZuo
Tutor: HuXinGen
School: Wenzhou University
Course: Organic Chemistry
Keywords: Isothermal titration calorimetry (ITC) amino acids chiral discrimination chiral alcohol enthalpic pair interaction coefficient
CLC: O621.25
Type: Master's thesis
Year: 2011
Downloads: 22
Quote: 0
Read: Download Dissertation

Abstract


Chiroselective process has become a central issue in the investigation of the origin of geochemistry and evolution of life. The molecular mechanism of chiral recognition is also a term which pervades a wide range of disciplines such as chemistry, biology, materials and pharmaceutics. For exploring weak nonbonding interactions in chiral molecular systems, the microcalorimetry is usually very useful. This paper consists of the following two parts:The first part: Five chiral diols and two kinds of nonchiral diols were choosen as research objects. The dilution enthalpies of all of them in dimethylsulfoxide （DMSO） + water mixtures have been determined respectively, using an isothermal titration calorimeter （ITC） at 298.15 K. On the basis of the McMillan-Mayer theory, the homochiral enthalpic pairwise interaction coefficients （hXX） of the sevev diols in the DMSO + water mixtures of various mass fractions （w = 0 to 0.3） have been calculated. The results are discussed from the point of view of solute-solute interaction and solute-solvent interaction. It was found that the method of ITC can differentiate the energies of homochiral interactions hXX between different pairs of optical isomers in aqueous solutions. The variations of with w for the four diols depend largely on the competition equilibrium between hydrophobic-hydrophobic, hydrophilic-hydrophilic and hydrophobic-hydrophilic interactions in DMSO + water mixtures.The second part: L-proline and L-hydroxyproline were choosen as research objects. By using Isothermal titration calorimetry （ITC）, the enthalpies of dilution of the two amino acids in pure water and various mass fractions （w = 0 to 0.3） of DMSO-H2O and DMF-H2O mixtures have been determined. The enthalpic interaction coefficients have been calculated based on the statistical thermodynamics theory of McMillan-Mayer. The influence of solvent-mediated solute-solute interaction on the values of enthalpic interaction coefficients has been discussed.

Related Dissertations

  1. Broiler Responses to Reduced-protein Diets Suppleme Nted with Synthetic Amino Acids and Small Peptides,S831.5
  2. Study on Synthesizes of N-methyl Pyrrole Derivatives and Application in Cigarette,TQ655
  3. Study on the Trophic Value of Blood Meal by Different Processes and the Effects of Supplements in Broiler Chicken,S831.5
  4. Research on Free Amino Acids Analysis Techniques of Flue-cured Tobacco and Application,S572
  5. Algebraic Structure of p53 Gene and Its Application,O153
  6. Study on the Chemical Constituents of Areca Nut,S792.91
  7. Ecophysiology Compensatory Mechanisms of Caragana Korshinskii after Clipping,S793
  8. In the grass carp (Ctenopharyngodon idellus) feed supplement microcapsules and crystal Amino Acids,S963
  9. Dual Effect Elicited by (Tyr~6)-γ2-MSH-6-12, and in Vivo Hyperalgesia Activity of Position 6-substituted Analogs Synthesis of Pharmaceutical Excipients Mono-O-(3-cholesteryloxycarbonyl) Propionyl Poloxamers,R914
  10. Effect of Cd on Nutrient Elements and Free Amino Acids of Kandelia Candel Seedlings,S718.4
  11. The Physiological Regulations of "Regulator" or "Conformer" Parasitoids on Their Host Plutella Xylostella,S476.3
  12. Effect of Amino Acids Composition and Carbohydrates Constitute on Mixed Rumen Fermentation in Vitro,S816
  13. Raccoon growth phase low - protein diets and amino acid requirements,S865.24
  14. Palladium Catalyzed N-Arylation Reaction of Aryl Chlorides and Synthesis and Application of Phosphorus Ligands,TQ203.2
  15. Study on Preparation and Related Process of Cocoon Silk Peptide and Mixed Amino Acid,TQ936.1
  16. A Dietary Survey and Analysis of Some Nutrients of Aba Kashin-Beck Disease Area,R151.41
  17. The Effect of Sealing Materials on Immature Wheat Embryos Culture, and the Cloning and Analysis of Alpha-tubulin Genes in Regeneration Organs,S512.1
  18. NIR Spectroscopy Model Construction and Application for Amino Acid Composition in Rice Grain,S511
  19. Effects of Freezing and Thawing Alternation on Soil Nitrogen Pool in the Alpine Meadow,S812.2
  20. The Research on the Process of Amino Acid Seweage Treatment,X703

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Properties of organic compounds > Chemical properties of organic reactions
© 2012 www.DissertationTopic.Net  Mobile