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Preparation and Characterization of Gelatin Magnetic Targted Drugs

Author: SongLiNa
Tutor: LiuTianQing
School: Yangzhou University
Course: Physical and chemical
Keywords: Iron oxide Mercaptopurine Isopropanol Glutaraldehyde Acyclovir MHD Magnetic fluid Weak magnetic Sodium dodecyl benzene sulfonate Magnetic composite
CLC: TQ460.1
Type: Master's thesis
Year: 2009
Downloads: 184
Quote: 0
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Abstract


1 Preparation and Characterization of weakly magnetic FeOOH nanoparticles using the sol-gel method the weakly magnetic FeOOH nanoparticles. Peptizers, ferric chloride as ferric hydroxide sol prepared with ferric sulfate. Sodium dodecylbenzene sulfonate, as a gelling agent, the precipitated iron hydroxide sol. Adsorbed sodium dodecyl benzene sulfonate FeOOH surface with ether which was extracted into ether, iron oxide ultrafine dried. By TEM, XRD, strong vibration magnetometer, Fourier transform infrared spectrometer, FeCl3 and Fe2 (SO4) 3 molar ratio of the crystal morphology and the drying temperature morphology, crystalline and magnetic . 2 Preparation of a ferromagnetic tetroxide ferrofluid and Table simple step synthesis acquisition adsorbed citrate hydrophilic iron oxide nanoparticles were prepared, this hydrophilic nanoparticles redispersing PEG6000 solution, highly dispersed can be prepared in an aqueous solution and stable magnetic fluid. By transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and strong vibration magnetometer, the magnetic fluid analysis and characterization. The amount of sodium citrate on the particle size, morphology and magnetic, NaCl, of gelatin and temperature of Fe3O4 nanoparticles and Fe3O4 gelatin magnetic composite nanoparticles morphology. 3. Preparation and characterization of the weak magnetic FeOOH gelatin nanoparticle drug coagulant isopropanol, glutaraldehyde as a curing agent prepared FeOOH gelatin composite nanoparticles using single cohesion and FeOOH and drugs wrapped in the nanoparticles prepared acyclovir FeOOH gelatin magnetic nanoparticle drug. With IR, TEM, XRD, strong vibration magnetometer FeOOH gelatin magnetic nano drug particle characterization. Explore the gelatin concentration, of isopropanol the amount of curing agent and curing time of FeOOH-gelatin composite nano-particles in particle size, morphology and magnetic. Determination of acyclovir FeOOH gelatin magnetic nanoparticle drug encapsulation efficiency and drug loading rate. Preparation and characterization of ferromagnetic iron oxide gelatin nanoparticle drug using single cohesion prepared Fe 3 O 4 magnetic the gelatin nano drug carrier, explore the preparation of magnetic nano the best ratio of microspheres. Their morphology by TEM analysis, the strong vibration magnetometer magnetic measurements, X-ray diffraction structural characterization. Preparation mercaptopurine magnetic gelatin nanoparticle drug, the strong vibration magnetometer by transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, differential thermal - thermal gravimetric analyzer targeting drug magnetic gelatin particles were characterized. Determination of the encapsulation efficiency and drug loading efficiency, mercaptopurine parcel rate reached 62.74% - 76.15%, are up to the pharmaceutical standard.

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