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Laryngeal Function Following Chemoradiotherapy for Nasopharyngeal Carcinoma

Author: XiaoLiu
Tutor: JiangJiaZuo；WangShengZi；ZouLiFen
School: Fudan University
Course: Clinical
Keywords: Nasopharyngeal Laryngeal function Objective voice school Aerodynamics Vocal cord mucosal wave
CLC: R739.63
Type: Master's thesis
Year: 2009
Downloads: 47
Quote: 0
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Abstract


To compare nasopharyngeal carcinoma patients receiving radiotherapy and chemotherapy in the near future with laryngeal function before treatment , from the objective voice learning , pronunciation air dynamics and vocal cord mucosa fluctuations quantitative evaluation of laryngeal function changes in patients with nasopharyngeal carcinoma after chemotherapy and preliminary explore pronunciation threshold of flow values ??and vocal fold mucosal wave measurements in the evaluation of laryngeal function . [ Method ] selected 16 patients with nasopharyngeal carcinoma patients with newly diagnosed , to rule out the influence factors of the larynx organic disease and smoking , measuring before radiotherapy and after radiotherapy in March laryngeal function evaluation parameter itself before and after comparison study . The objective laryngeal function evaluation parameters including : objective voice parameters ( baseband , baseband standard deviation , noise harmonics than the fundamental frequency perturbation , amplitude perturbation ) , pronunciation aerodynamic parameters ( maximum phonation time , comfortable tone sound sects Pronounce pressure, threshold pressure values, pronunciation threshold flow value , the mean glottal airflow) , and vocal cords mucosal wave parameters ( left, the difference between the upper and lower edges of the right vocal cord , amplitude) . [Results] The March when compared with radiotherapy after radiotherapy , the fundamental frequency significantly decreased ( P = 0.005 ) , pronunciation threshold flow improved significantly ( P = 0.03 ) , the comfortable tone subglottic pressure also raise no data significant difference , other The item objective voice parameters , aerodynamic parameters and vocal cords difference between the upper and lower edges and amplitude was no significant difference . [Conclusion] The the objective vocal learning and pronunciation aerodynamics measurement can be used for the quantitative evaluation of nasopharyngeal carcinoma after radiotherapy and chemotherapy laryngeal function pronunciation threshold flow value compared with the the pronunciation threshold pressure value is more sensitive .

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CLC: > Medicine, health > Oncology > Department of Otolaryngology tumor > Pharyngeal tumors
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