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Worldwide, cardiovascular and cerebrovascular disease incidence gradually increased, and one ischemic stroke in the elderly is one of the most common neurological diseases, morbidity mortality rate is very high, to bring serious social and family consequences. In recent years, on cardiovascular disease risk factors found, dyslipidemia, and ischemic heart disease morbidity and mortality are closely related, and on the relationship between dyslipidemia and stroke have also been a large number of epidemiological investigations and trials confirmed proactive statin lipid-lowering therapy for secondary prevention of stroke have a great benefit, but for the dyslipidemia associated with the incidence of stroke has yet to have a unified conclusion. In this study, a retrospective collection of blood lipids in patients with ischemic stroke cases, explore dyslipidemia and ischemic stroke as well as the relationship between its various subtypes. Objective: To study dyslipidemia and ischemic stroke between its various subtypes. Subjects and Methods: 516 cases of ischemic stroke patients and normal control group, 131 cases of stroke risk factors and lipid circumstances, including serum total cholesterol (Total Cholesterol, TC), triglycerides (Triglyceride, TG), low density lipoprotein (low density lipoprotein, LDL), high density lipoprotein (high density lipoproteins, HDL), apolipoprotein-A1 (apoprotein-A1, Apo-A1), apolipoprotein B (apoprotein-B, Apo-B ) and lipoprotein (a) [lipoprotein (a), Lp (a)] and other indicators for statistical analysis and comparison. And is selected from the 131 cases more complete information ischemic stroke patients according to TOAST classification criteria (trial of ORG 10,172 in acute stroke treatment, TOAST) were typed, the lipid levels in each subgroup, then compared with the control group, Research dyslipidemia and ischemic stroke subtype relationship. Results: 1. Ischemic stroke and serum lipid levels Relationships: HDL levels in patients with ischemic stroke 1.08 ± 0.31mmo / L compared with the control group, 1.21 ± 0.32mmol / L was significantly lower (P <0.05), TC / HDL ratio 4.55 ± 1.47, 4.09 ± 1.22 compared with the control group was significantly increased. The remaining blood components, including TC, TG, LDL were not found significant differences. 2 subtypes of ischemic stroke and the relationship between lipid levels: According to TOAST classification, 131 cases of ischemic stroke patients, 66 cases of atherosclerotic stroke (large artery atherosclerosis, LAA), 19 patients undergoing cardiac origin cerebral embolism (cardioaortic embolism, CE), 32 patients with small artery occlusion or lacunar infarct (smallartery occlusion, SAO), respectively, compared with the control group lipid levels. LAA group and the CE group, SAO group, HDL levels were significantly lower than the control group, and their TC / HDL ratio was significantly higher than the control. The remaining blood components have no statistically significant results. The LAA group and SAO group as atherosclerosis group compared with the control group, found that in addition to the above results, arteriosclerosis group TC, TG and LDL levels were rising trend emerged, statistical differences narrowed. Other causes of stroke (SOE) and unexplained stroke (SUE) is shown with each component lipids were not correlated. Conclusion: 1.HDL in patients with ischemic stroke was significantly reduced, reducing its protective factors may be one of the causes of stroke. (2) For the purposes of atherosclerotic ischemic stroke, TC, TG and LDL may be related to a direct correlation. 3 For non-atherosclerotic ischemic stroke, the incidence of dyslipidemia and its stroke is not relevant. 4.TC/HDL ratio is a measure of dyslipidemia and ischemic stroke between one of the indicators. 5 lipids and stroke relationship requires further stroke-based genotyping based on the larger sample size studies.
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