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Study on the Mechanism of the Retardation Effect of Galla Chinensis and Enamel Organic Matrix on Enamel Demineralization

Author: ZhangAnSheng
Tutor: TangRongYin；ZhangYing
School: Fourth Military Medical University
Course: Clinical Stomatology
Keywords: Gallnut Enamel organic matter Crystal structure Enamel microporous Enamel permeability
CLC: R285.5
Type: Master's thesis
Year: 2009
Downloads: 50
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Abstract


Caries process of demineralization and remineralization of the dental hard tissue homeostasis, and how to adjust the various factors affecting the inhibition of dental hard tissue demineralization and promote remineralization of caries prevention. Very few the enamel organic matter content, weight accounted for only 1% of the enamel as a whole, but the study found that it has a role of inhibition of enamel demineralization, the mechanism may be organic matter can inhibit the diffusion of ions in the enamel. The natural medicine gallnut is research in recent years more of a novel anti-caries drugs, inhibition of enamel demineralization effect of fluoride, and the experiment proved that the inhibition of enamel demineralization and enamel organic matter related mechanisms are unclear . To more depth to explore gallnut with the enamel organic matter inhibition mechanism of enamel demineralization, this study used a variety of experimental methods the expedition gallnut with enamel organic matter on the enamel porosity and permeability. In this study, a total of four experiments: In experiment 1, gallic inhibit of enamel demineralization best concentration screened using freshly extracted teeth vitro prepared 56 enamel specimens were randomly divided into 7 groups. With de-ionized water and 4mg/ml 8mg/ml, 16mg/ml, 30mg/ml and 60mg/ml, 120mg/ml of nutgall solution on enamel surface treatment, the use of artificial demineralization demineralization solution. The microradiography technology analysis, comparing the amount of demineralization and demineralization depth. Automatic potentiometric titrator groups demineralization solution Ca 2 concentration was measured. Results: the 16mg/ml nutgall, with significant inhibition of enamel demineralization inhibition of enamel demineralization effect; When the concentration of 30mg/ml, to achieve the best, with a higher concentration of the treated group compared to no statistically significant. Experiment II enamel crystal structure gallnut before and after the X-ray diffraction analysis of 10 isolated teeth enamel part was cut and ground into powder, were randomly divided into two groups, one deal, another group with 30mg/ml nutgall solution treatment, followed by, respectively, the line of powder X-ray diffraction analysis. The results show that: the enamel crystal size compared with the pre-processed after the processing of the gallic becomes slightly smaller, the crystal structure was no obvious change. Experiment III gallnut and enamel organic matter of enamel porosity cut 10 freshly extracted isolated teeth enamel part 0 ℃ under the conditions of ground into powder, were randomly divided into two groups, one group does not deal with the normal enamel group marked labeled, marked another group using 10% NaClO treatment to go organic enamel group; then were randomly remove from the two sets of powder half use the 30mg/ml nutgall solution processing normal enamel gallnut treatment group and go the organic enamel Gallnut treatment group; using physical adsorption instrument to measure the specific surface area and micropore volume of each group of samples. The results show: the removal of organic matter, the specific surface area of ??the enamel significant increase (P lt; 0.05), micropore volume did not change significantly (P gt; 0.05); future gallnut, the specific surface area and pore volume of normal enamel significant reduce (P lt; 0.05), go organic matter in the specific surface area and pore volume of the enamel did not change significantly (P gt; 0.05). Factorial analysis showed gallnut and enamel organic matter than the influence of the surface area and micropore volume of the enamel have a significant interaction between. Experiment IV, gallnut and enamel organic matter of enamel permeability select five freshly extracted teeth in vitro, using the hard tissue slicing mechanism prepared enamel slice thickness of 200μm, each cut four teeth were randomly divided into four groups, normal enamel group after treatment, respectively marked as to organic enamel group normal enamel Gallnut treatment group, to the treatment group of the organic enamel gallic. CLSM line FRAP method determination of the permeability of the enamel. The results are as follows: the removal of organic matter, the diffusion coefficient of the enamel significant increase (P lt; 0.05); the future gallnut, the diffusion coefficient of the normal enamel significantly reduce (P lt; 0.05) away organic enamel no significant change (P gt; 0.05). Factorial analysis of the results, the Chinese gall and enamel organic matter of enamel permeability has a significant, and the interaction between the two.

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