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Objective: To study the inflammatory network and endothelial cells, platelet activating impact of SLE autoimmune of thrombophilia pathological process, safflower injection combined with Western medicine for SLE thrombophilic state intervention to provide a theoretical basis for traditional Chinese medicine to treat immune thrombophilia . Method: observation of 85 patients with systemic lupus erythematosus (systemic lupus erythematosus, SLE) patients, including mitigation of 31 cases, the activities of 54 cases. Observed by enzyme-linked immunosorbent assay (ELISA) interleukin -6 (interleukin-6, IL-6), IL-8, IL-10, IL-18, soluble thrombomodulin protein (solubility thrombomodulin sTM), soluble vascular cell adhesion molecule -1 (solubility vascular cell adhesion molecule-1, sVCAM-1) and flow cytometry (flow cytometry, FCM) to detect neutrophils of CD11b, P-selectin (CD62p), platelet-activating membrane glycoprotein Ⅱ b / Ⅲ a binding sites (PAC-1) and other inflammatory adhesion factor, vascular endothelial cells and platelet-activating factor expression. Results: 1 inflammatory adhesion molecules IL-6, IL-8, IL-10, IL-18 and CD11b expression (P lt; 0.05) in SLE patients with active are abnormally high levels, such factor levels in disease remission When close to normal controls (P gt; 0.05). 2, vascular endothelial cell activating factor sTM and sVCAM-1 levels in the serum of patients with active SLE was significantly higher than in remission and the control group (P lt; 0.05), ease the control group, no differences (P gt; 0.05). SLE patients with active platelet-activating factor CD62p levels were significantly higher (P lt; 0.05), remission restore nearly normal (P gt; 0.05). PAC-1 compared with the control group increased in SLE patients with active and remission, but no significant change (P gt; 0.05). Conventional western medicine treatment in patients with active SLE, IL-6, IL-8, IL-10, IL-18, CD11b, of sTM, sVCAM-1 and CD62p levels than before treatment were significantly decreased (P lt; 0.05) . Safflower injection combined with conventional western medicine, the indicators are lower than before treatment with conventional western medicine treatment group (P lt; 0.05). Conclusion: SLE with active presence of the abnormal inflammation adhesion factor release, induce or aggravate pathological basis of immune inflammatory thrombophilia. Pathological endothelial cell activation and platelet activation is involved in active SLE one of the important factors for thrombophilia. 3, the conventional western medicine, traditional Chinese medicine safflower combined with Western medicine treatment programs can effectively alleviate the SLE disease improve immune inflammatory suppository state; Chinese drug saffron significant than with Western medicine combined with Western.
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