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The Levels and Effect of the VEGF、TNF-α and IL-6 after Balloon Injury in Rat Carotid Artery

Author: ZhouBo
Tutor: BaiFeng
School: Lanzhou University
Course: Department of Cardiology
Keywords: Rat TNF-α IL-6 VEGF Ballon Injury
CLC: R543
Type: Master's thesis
Year: 2009
Downloads: 67
Quote: 0
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Abstract


Objective To investigate the Levels and Effect of Vascular endothelial growth factor（VEGF）、tumor necrosis factor-α（TNF-α） and InterLeukin -6（IL-6） after balloon injury in rat carotid artery.Methods 60male Sprague-Dawley rats were divided into the control group （A,no injury）、the model group（B,the simple injury）、thalidomide small doses group(C,the simple injury,100 mg·kg-1·d-1 of thalidomide was administered after conventional carotid artery denudation injury) and the high doses group(D,the simple injury,200 mg·kg-1·d-1 of thalidomide was administered after conventional carotid artey after arten injury).The rats were killed at 7、14、28days.Serum concentrations of VEGF were measured by enzyme-linked immunosorbent assay（ELISA） and serum concentrations of TNF-α、IL-6 were measured radioimmunoassay immediately.Results Serum concentrations of VEGF、TNF-αand IL-6 were significantly higher in B、C and D group throughout the experiment in comparison with A group（P<0.05）;Compared with the B group,serum concentrations of TNF-α、IL-6 and VEGF were markedly reducedin A、C and D group in different times after injury（P<0.05）;Compared with the C group,Serum concentrations of VEGF、TNF-αand IL-6 were also markedly reduced in D group in different times after injury（P<0.05）.Conclusions TNF-α、IL-6 and VEGF were high expressed obviously after arterial injury.We found that thalidomide,effectively inhibits Serum IL-6,TNF-αand VEGF in balloon-injured rat carotid arteries.The level of three factors were correlated with the dose of thalidomide.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Vascular disease
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