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The Effect of 17β-Estradiol on the Intestinal Motiliy of Ovariectomized SD Rats

Author: LiangJieLing
Tutor: YangDongZuo
School: Central South University
Course: Department of Gastroenterology,
Keywords: 17β-estradiol Intestinal propulsive ratio Small intestinal smooth Estrogen receptor antagonist
CLC: R965
Type: Master's thesis
Year: 2011
Downloads: 22
Quote: 0
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Abstract


Objective To investigate the impact of 17β-estradiol in vitro and in vivo intestinal motility ovariectomized SD (Sprague Dawley) , and its possible mechanism . Methods ovariectomized SD rat models , in vivo studies with different concentrations of 17p- estradiol and Comparative rat intestinal propulsive than differences in order to understand the changes in the transmission function of the small intestine . The in vitro production of isolated small intestinal bowel , small intestine smooth muscle tension conversion devices and biological function of the system and other equipment , measurement carbachol , 17β- estradiol , the estrogen receptor antagonist fulvestrant (Fulvestrant) different combinations and tension changes in the concentration effect . Results 1.17β- estradiol lower than ovariectomized SD rat small intestine propulsion , and with the increase of the concentration , the stronger the inhibition . 2 simple 10-4mol / L carbachol ovariectomized SD rat small intestine smooth muscle tension can enhance 17β-estradiol inhibit smooth muscle of the small intestine caused by carbachol elevated , with the 17p- the increase in estradiol concentration , and the inhibition strength is also enhanced, and this estrogen caused by inhibition in the estrogen receptor antagonist fulvestrant was significantly eliminate . The conclusion 1.17β- estradiol inhibit intestinal transit function in ovariectomized SD rats , its concentration was positively correlated , may play a role in the small intestine motility weakened . 2.17p- estradiol carbachol ovariectomized SD rat small intestine smooth muscle tension elevated play an inhibitory concentration was positively correlated , this inhibitory receptor antagonist fulvestrant eliminated . 3.17β- estradiol in ovariectomized rats away from the small intestine smooth muscle contraction inhibition may be related with female SD rat small intestine estrogen receptor .

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