Dissertation > Excellent graduate degree dissertation topics show

Study of Relationship between Delayed Rectified Potassium Current and Drug-induced Arrythmia

Author: JiangLei
Tutor: PaErHaTi·KeReMu
School: Xinjiang Medical University
Course: Pharmacology
Keywords: Haloperidol Delayed rectifier potassium current Patch-clamp technique
CLC: R595.3
Type: Master's thesis
Year: 2011
Downloads: 21
Quote: 0
Read: Download Dissertation

Abstract


Objective : To observe the different concentrations of haloperidol on guinea pig ventricular myocytes delayed rectifier potassium current (IK) , and to explore the ionic basis haloperidol arrhythmogenic . Methods : enzymatically dissociated guinea pig ventricular myocytes , whole-cell mode voltage clamp patch clamp delayed rectifier potassium channel current role of guinea pig ventricular myocytes treated with different concentrations of haloperidol , all records are made to the same program record haloperidol intervention before and after the impact of the delayed rectifier potassium ion channel currents . Results: individual cells , were given 0.3μmol · L- 1 , the , 1.0 μ mol of L- 1 , L -1 3.0μmol haloperidol , delayed rectifier potassium ion channel currents decreased in varying degrees ; the test voltage 70mV , delayed rectifier potassium current before administration ( 16.6604 ± 1.5717 ) pA / pF , respectively, reduce to ( 5.0255 ± 1.9372 ) pA / pF ( 9.8572 ± 3.9002 ) pA / pF ( 7.1794 ± 1.816 ) pA / pF (n = 7, P lt; 0.01), and 0.3μmol · L-1 more obvious than the other two concentrations of haloperidol on the inhibition of the delayed rectifier potassium current . Conclusion: Our study found that haloperidol delayed rectifier potassium channel current inhibition , and a dose - dependent manner . Haloperidol inhibited the delayed rectifier potassium ion channel currents , action potential duration extend lead to arrhythmia haloperidol arrhythmogenic effect may be related to the role of potassium channels .

Related Dissertations

  1. Naloxone on rat ventricular myocytes L-type calcium channels,R965
  2. Function and Molecular Expression of Two Types of Potassium Channels in Interstitial Cells of Cajal from Diabetic Gastroparasis Rats,R587.2
  3. The Effect of Ca2+ Released from Ryanodine Receptor Typer 2 on SK2 Channel in MyoCardium Cells,Q257
  4. Hydrochloric acid Chang Xin Sha Star inhibition study of the molecular mechanisms of HERG potassium channel,R96
  5. Aripiprazole treatment of tic disorders in clinical and experimental studies and related changes in immune function,R749.94
  6. Effects of Haloperidol on mRNA Expression of Potassium Channel and Sodium Channel in Myocytes of Rabbit,R96
  7. Effects of Fluconazole on Electrophysiological Functions of HERG Channel,R96
  8. Effects of EGCG on the Voltage-gated Potassium Channels in Primary Cultured Hippocampal Cells,Q42
  9. Pumping dirty flat on twitch - Tourette Syndrome Clinical Observation,R749.94
  10. Mechanism of the Cardiovascular System of SWNTs in Rats,Q463
  11. Modulation of Transient Outward and Delayed Rectifier Potassium Channels in Acutely Isolated Hippocampal Neurons by Lanthanum,Q42
  12. Clinical Observation on Treatment of Patients with Tourette Syndrome by Integrative Chinese and Western Medicine,R749.94
  13. Hypotonicity Inhibited ATP-activated Currents in Rat Trigeminal Ganglion Neurons,Q42
  14. Effect of Nav1.5-E3 Antibody on Sodium Current in Guinea Pig Ventricular Myocytes,R541
  15. PROPERTIES AND MODULATIONS OF BKCa CHANNELS IN HYPOTHALAMIC NEURONS,Q421
  16. Effects of Monoclonal Antibody of NMDA Receptor on NMDA-activated Current in Acutely Isolated Rat Hippocampal Neurons,R741
  17. The Effects of Haloperidol on the Intelligence Factors、Secretion of Prolactin and Thyroid-stimulating Hormone of Children with TS,R749.94
  18. Effects of N-n-butyl Haloperidol Iodide （F2） on Inwardly Rectifying Potassium Channels of Cardiac Myocytes,R96
  19. Electrophysiologic Effects of GFA on Ventricular Myocytes of Guinea Pigs and Rats,R285.5
  20. Effects of LVFX and AX on I_k Currents in Guinea Pig Ventricular Myocytes,R96

CLC: > Medicine, health > Internal Medicine > Systemic disease > Poisoning and chemical damage > Drug-induced diseases
© 2012 www.DissertationTopic.Net  Mobile