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Expression of Urinary Soluble Fms-like Tyrosine Kinase-1 with Preeclampsia

Author: ZhangHaiZhen
Tutor: JinXianYu
School: Dalian Medical University
Course: Obstetrics and Gynaecology
Keywords: Preeclampsia Soluble vascular endothelial growth factor receptor-1 Urine
CLC: R714.2
Type: Master's thesis
Year: 2009
Downloads: 23
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Abstract


Objective: Preeclampsia is a pregnancy-specific disease, although it has done a lot of research, but its etiology and pathogenesis remains unknown. Commonly used in clinical diagnostic methods for the monitoring of blood pressure, urine protein analysis and serum uric acid, etc., but its specificity and sensitivity is not ideal. Current studies suggest that angiogenic factors and anti-angiogenic factor imbalance is a major cause of preeclampsia, which is mainly concentrated in the placenta produces a soluble vascular endothelial growth factor receptor -1 (soluble fms-like tyrosine kinase-1, sFlt-1) on. sFlt-1, vascular endothelial growth factor (VEGF) is an inhibitory receptor, can be combined with VEGF and placenta growth factor (PlGF) and to play a physiological role in inhibition of both. Experiments show preeclampsia placenta and the blood has a high concentration of sFlt-1 exists in many types of blood circulation in the sFlt-1, VEGF and PlGF concentration changes found in serum sFlt-1 in preeclampsia and normal pregnancy comparison between patients have significantly increased, and can be used to determine the condition of the disease. We studied urinary sFlt-1 will be similar to the changes in the blood, can be used in the diagnosis; while comparing the factor with several commonly used clinical indicators of the pros and cons, to seek a non-invasive, sensitivity and have a high specificity of laboratory diagnostic markers. Methods: no other complications, unused effect of vasoactive drugs in patients with severe preeclampsia and 16 cases of non-severe preeclampsia, 13 cases of normal pregnant women the control group 15 cases. Enzyme-linked immunosorbent assay (ELISA) measuring the urine of pregnant women hospitalized random sFlt-1 levels; using biuret colorimetric determination of urinary protein; using phosphotungstic acid reduction of serum uric acid. Results: (1) the study group and the control group in age, weight, gestational age, maternal time and sampling difference was not statistically significant, severe preeclampsia gestational age was significantly less than non-pre-eclampsia and control groups; (2) serum uric acid in severe, non-severe preeclampsia and normal pregnant group were 380,312,209 umol / L, qualitative urine protein levels in all groups were 2.88,1.31,0.37 (P lt; 0.05), difference was statistically significant; (3) Urine sFlt-1 concentrations in severe, non-severe preeclampsia group and the normal group were 2986.25 ± 647,2189.38 ± 658,1231.60 ± 974mg/ml, severe preeclampsia group was significantly higher than non-severe pre-eclampsia and the control group (P lt; 0.05), and with exacerbations urine sFlt-1 gradually increases; (4) qualitative urine protein and serum uric acid there is a correlation between the qualitative urine protein and urine sFlt correlation exists between -1; (5) urinary sFlt-1 diagnosis of severe preeclampsia qualitatively superior sensitivity and specificity of urinary protein and serum uric acid, and urinary sFlt-1 ≥ 2676mg/ml as the cutoff point, the diagnosis of severe child The accuracy of preeclampsia best. Conclusions: (1) sFlt-1 in the pathogenesis of preeclampsia play an important role, urine sFlt-1 can be used to determine the condition of preeclampsia; (2) Determination of urinary sFlt-1 is a non-invasive, fast MOV, and is used to determine the condition of severe preeclampsia urinary sFlt-1 is better than qualitative proteinuria; (3) Urine sFlt-1 ≥ 2676mg/ml can have a positive significance.

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CLC: > Medicine, health > Obstetrics and Gynaecology > Obstetrics > Pathological pregnancy ( abnormal pregnancy )
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