|
[Objective] To understand the adult male kidney transplant recipients serum estradiol E2, the level of testosterone Te, Te/E2 value, lipids (including cholesterol and triglycerides), long after transplantation and the recent arterial pressure and serum cystatin C (Cys C) and serum creatinine (Scr) correlation. Explore the relationship of the male sex hormone levels with transplant renal function. [Methods] 76 cases of adult male after renal transplantation recipients, determination of serum testosterone, estradiol levels calculated testosterone / estradiol values, simultaneous determination of fasting blood cholesterol and triglyceride levels, a recent arterial pressure and Cys C, Scr value. As a normal control group of 23 patients to the same period in outpatient health or related diseases male patients. To the same period in the outpatient diagnosis of uremia, 12 cases of male patients not yet on dialysis as uremia control group. Study taking immunosuppressant cyclosporine, mycophenolate mofetil prednisone and tacrolimus complex Cellcept prednisone divided into two groups (referred to as CsA and FK506 group), respectively, to 42 and 34 people. The data obtained serum testosterone, estradiol, Te/E2, blood cholesterol, triglycerides, mean arterial pressure, long after transplantation Cys C and Scr correlation analysis. Results】 ① CsA group average systolic blood pressure, serum triglycerides, Cys C and Scr water were higher than FK506 group (P lt; 0.05). ② CsA group and the the FK506 group average systolic blood pressure, serum cholesterol, triglycerides, estradiol, Cys C and Scr levels were higher than normal control group (P lt; 0.05); testosterone levels below the normal control group (P lt; 0.05). The 3 CsA group and the the FK506 group average systolic blood pressure, serum cholesterol, triglycerides, Cys C and Scr water averaged less than the the Uremic control group (P lt; 0.05); testosterone levels were higher than the uremic group (P lt; 0.05) . ④ CsA group after renal transplantation, the average systolic blood pressure, serum cholesterol, serum testosterone level of Cys C showed a positive linear correlation (P lt; 0.05). Testosterone / estradiol value Cys C below after renal transplantation, long and serum cholesterol and Cys C in, but better than the other. ⑤ FK506 group, after renal transplantation, the mean systolic blood pressure, serum cholesterol, triglycerides, serum testosterone and Cys C levels showed a positive linear correlation (P lt; 0.05). Testosterone / estradiol value Cys C below after renal transplantation, the average systolic blood pressure and serum cholesterol and Cys C, but better than the other. ⑥ CsA group after renal transplantation, the average systolic blood pressure, serum cholesterol levels were Scr was positive linear correlation (P lt; 0.05). The FK506 group average systolic blood pressure, serum cholesterol levels were Scr linear positive correlation (P lt; 0.05). The correlation is generally lower than indicators Scr and Cys C correlation. The ⑦ CsA and FK506 group testosterone / estradiol values ??and Cys c values ??showed a positive linear correlation (P lt; 0.05) positive linear correlation (P; the CsA group testosterone / estradiol values ??and Scr value lt; 0.05); FK506 group, testosterone / estradiol value and the the Scr value of wireless relationship (P gt; 0.05); uremia group and the normal group testosterone / estradiol values ??and Cys c and Scr values ??are wireless relationship (P gt; 0.05) ⑧ CsA and FK506 group in the testosterone / estradiol values, Cys C value argument two straight line, that the slope of the two straight lines are different. [Conclusion] 1 male recipients after renal transplantation blood pressure, blood lipids and estradiol levels, testosterone levels decline. Indicators compared with uremia, have improved significantly. After renal transplantation recipients of CsA blood pressure, lipids and renal worse FK506 group, two groups of testosterone, estradiol levels had no significant difference. 3 after renal transplantation male recipients Cys C and Scr were positively correlated. Long after renal transplantation in the experiment, the average systolic blood pressure, serum cholesterol, testosterone / estradiol value level indicators Cys C correlation are better than the correlation with Scr. 4 in the human body for the first time confirmed that the correlation between serum testosterone and estradiol levels after renal transplantation and graft function. Especially blood ratio of testosterone and estradiol and Cys C positive linear correlation, but the strength is less than the average systolic blood pressure and serum cholesterol levels slightly smaller, and by the use of CsA or FK506 impact.
|