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The Study of Echocardiography、cytokines TNF-α、TGF-β and Heart-type Fatty Acid Binding Protein of Swimming Athletes Before and after Altitude Training

Author: LiuHongJun
Tutor: MaYun
School: Shanghai Institute of Physical Education
Course: Sports Medicine
Keywords: Altitude Training Swimmers Echocardiography Cytokines Myocardial injury Athletes heart function
CLC: R87
Type: Master's thesis
Year: 2011
Downloads: 39
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Abstract

Echocardiography research purposes swimmers participating in altitude training, changes of cardiac morphology, structure and function of its three weeks before and after training, while filtering out sensitive echocardiographic indices altitude training to reflect changes in heart function. Immunological parameters of the three weeks before and after altitude training athletes detection of altitude training on cardiac function is closely related to the cytokines tumor necrosis factor (TNF-α) and metastatic growth factor (TGF-β), and cardiac function. New indicator of myocardial injury biomarkers detected twice in the three weeks before and after training - the heart-type fatty acid binding protein (H-FABP) to observe the changes of H-FABP swimmer altitude training, explore its ability as a myocardial injury their variation of cardiac function changes. Research methods for the study of 35 countries to participate in the altitude training Swimmers object. The first altitude training before the beginning of the week (2009.12.28-29) at 7:00-10:00, swimmer echocardiography as a basis of reference values, respectively, to the M-mode echocardiographic measurements of cardiac morphology, structure indicators: left ventricular end-systolic anteroposterior diameter (LVSD) and left ventricular end-diastolic anteroposterior diameter (LVDD), left ventricular septal thickness, left ventricular posterior wall thickness; two-dimensional echocardiographic measurements of left ventricular systolic function and right ventricular morphology indicators: anteroposterior diameter of the left atrium, right ventricular diameter, right atrial transverse diameter, and calculated left ventricular end-systolic volume (ESV), left ventricular end-diastolic volume (EDV), cardiac output (CO), cardiac output (SV), left ventricular ejection fraction (EF), left ventricular fractional shortening rate (FS); Doppler mode measurement of left ventricular diastolic function parameters: peak early diastolic mitral annular velocity (VE), left atrial systolic peak speed (VA) , and calculate the VE / VA; Doppler echocardiography to detect left ventricular Tei index, right ventricular Tei index. After three weeks of acclimatization, high-intensity, large load exercise training, third weekend (2010.1.18-19) again in the evening 7:00-10:00 echocardiography. Will be detected twice the ultrasound echocardiography indicators for the t-test statistical analysis, changes in cardiac function observed swimmer after altitude training, and filter out sensitive echocardiographic indices altitude training to reflect changes in heart function. First weekly (2009.12.28) blood early in the morning at 7:30, the alternate test of TNF-α, TGF-β and H-FABP. Three weeks after training third weekend (2010.1.18) early in the morning at 7:30 again blood the alternate test related indicators. Enzyme-linked immunosorbent assay (ELISA) method to test the level of concentration. Before and after the t-test were detected twice TNF-α, TGF-β, and H-FABP observed variation trends of TNF-α and TGF-β, altitude training on cardiac function is closely related cytokines TNF-α and the impact of the TGF-β, and cardiac function. Observed trend of the variation of the H-FABP, to explore its ability to serve as a new indicator of myocardial injury, and to investigate the variation of changes in cardiac function. The results reflect cardiac morphology and structure, left ventricular systolic function, left ventricular diastolic function of the indicators are not significantly changed (P gt; 0.05). Reflect the overall function of left ventricular Tei index (P lt; 0.01) and reflect the overall right heart function Tei index (P lt; 0.05) three weeks before and after training with the obvious differences, and showed a trend of reduced. TNF-α, TGF-β in the three weeks before and after training did not change significantly, no statistical significance (P gt; 0.05). H-FABP has a very significant difference (P lt; 0.01), and showed a reduced trend. Conclusion 1. Altitude training before and after the swimmer left ventricular, right ventricular Tei index showed a reduced trend, suggesting that the enhanced global cardiac systolic and diastolic function. Compared with conventional echocardiography, Tei index can be used as a sensitive indicator of early evaluation of cardiac function. 2. Significant changes in altitude training before and after the swimmer heart function. Prompted altitude training can indeed improve level of swimmer heart function. TNF-α, TGF-β detected before and after the three weeks of training did not change significantly. TNF-α may not be mediated negative heart effects, not a downward effect on cardiac function. Taking into account the decline in H-FABP, TGF-β may play a positive biological effects, protection of the ischemic myocardial cells antagonize myocardial injury, to maintain the normal function of the heart. Minimize detection of myocardial injury markers before and after the three weeks of training material H-FABP presented with exercise training reduced trend can try as a new indicator of myocardial injury, suggesting myocardial injury, swimmer heart function after altitude training enhanced synchronization positive change.

The Study of Echocardiography、cytokines TNF-α、TGF-β and Heart-type Fatty Acid Binding Protein of Swimming Athletes Before and after Altitude Training

Abstract

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