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Type 2 diabetes mellitus (T2DM) is a Chinese context Diabetes, insulin resistance (IR) is one of its important in the pathogenesis is also characteristic changes of T2DM. In this paper, literature review, theoretical discussion, experimental research on traditional Chinese medicine JieDuTongLuo Tiaogan loose control T2DM, IR for a more systematic study. Focuses on the \sex. And through experimental studies have found JieDuTongLuo Tiaogan bulk can reduce IR, increased insulin sensitivity, which plays a role in prevention and treatment of T2DM, IR on the edge, with a strong innovation and practicality. A literature review 1.1 insulin resistance in type 2 diabetes research from ancient Chinese medicine and modern medicine for T2DM, IR nonaggressive understanding of the etiology and pathogenesis of exploration, diagnosis and treatment of Chinese medicine, progress and progress in prevention and treatment of T2DM mechanisms were reviewed, and current Syndromes and research in areas such as lack of normative research issues and prospects Commentary. 1.2 Type 2 Diabetes Insulin Resistance modern medical research at home and abroad in recent years on glucose and lipid metabolism in type 2 diabetes in the mechanism of insulin resistance latest research were reviewed. 2 Theory of the use of traditional Chinese medicine theory, the theory of the pathogenesis of Diabetes, therapeutic principle were discussed, that \Combined with modern research, presented the liver's role in the mechanism of insulin resistance, and described the \Discusses JieDuTongLuo Tiaogan law to combat insulin resistance by improving the scientific T2DM for Diabetes research ideas and therapies provide a theoretical basis. 3 Experimental studies JieDuTongLuo Liver Powder on experimental diabetic rats with high sugar high fat diet plus streptozotocin (STZ)-induced rat model of experimental DM, the normal control group, DM model group, positive the control group (DM metformin, DM pioglitazone)) and herbal experimental group (DM JieDuTongLuo Liver Powder), experimental observation of the indicators. The results showed that JieDuTongLuo Tiaogan bulk can significantly improve the general state of DM rats with hypoglycemic, lipid-lowering, reduce IR, increased insulin sensitivity, compared with DM model group were significantly statistically significant (P lt ; 0.01); can reduce body weight in obese rats with DM model group were significant statistical significance (P lt; 0.01); Tips JieDuTongLuo Liver Powder on experimental DM rats has good regulation role in glucose and lipid metabolism and having improved IR, to increase insulin sensitivity. 4 Clinical Research JieDuTongLuo Liver Powder treatment of obesity with type 2 diabetes 35 cases of clinical study JieDuTongLuo Liver Powder on obese patients with type 2 diabetes blood sugar, blood lipids, body weight and serum inflammatory marker C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1) levels. Let Chinese medicine and western medicine treatment group, 35 cases of the control group 35 cases, the treatment group taking JieDuTongLuo tiaogan loose the control group, western medicine metformin therapy, treatment of 4 weeks. Comparison of clinical efficacy were observed before and after treatment glucose, lipids, body mass index, changes in inflammatory markers. Treatment group than the control group; treatment group before and after treatment blood glucose, cholesterol, body mass index, levels of inflammatory markers were significantly different. JieDuTongLuo Tiaogan scattered in the treatment of obesity, type 2 diabetes, hypoglycemic, lipid-lowering aspects of significant clinical efficacy and decreased serum CRP and MCP-1 levels and other markers of inflammation.
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