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Expression of Erythropoietin and Erythropoietin Rece-ptor in Non-small Cell Lung Cancer and Correlation with Microvessel Density

Author: YuZuoZuo
Tutor: DanLi
School: Xinjiang Medical University
Course: Oncology
Keywords: non-small cell lung cancer erythropoietin erythropoietin receptor Microvessel density
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 16
Quote: 0
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Abstract


OBJECTIVE:Erythropoietin and Erythropoietin receptor (EPO-R) is expressed in many kinds of tumors.The EPO/EPO-R signaling is involved in tumor cell proliferation angiogenesis,and invasion.This study was to detect the expression of EPO-R in non-small cell lung cancer (NSCLC),and explore its correlation to angiogenesis. METHODS:The expression patterns of EPO and EPO-R in human lung tissues were detected by immuno-histochemistry, from 58 untreated NSCLC patients for whom clinical data were available, with tissues from adjacent tissue and 45 benign lesions as control, to analyze the expression patterns of EPO/EPO-R and clinical pathological factors. RESULTS:①he positive rate of EPO and EPO-R in NSCLC was significantly higher than those in the control tissues(P=0.000). The result shows that the expression patterns of were unrelated to age, sex, smoke,pTNM stage, histological type, histological grade and lymph node metastasis(P>0.05).②MVD were significantly higher than those in the control one(P=0.000).Increased MVD was correlated to lymphnode metastasis,advance stage.③The MVD in EPO/EPO-R positive patients was significantly higher than that in EPO/EPO-R negative patients (P=0.000). CONCLUSIONS:High expression of EPO/EPO-R in NSCLC patients suggest they may be involved in tumorigenesis. EPO/EPO-R expression and MVD are closely related,they might be an endogenous stimulant of angiogenesis during the progression of non-small cell lung cancer. The non-small cell lung cancer patients with anemia in the course of treatment with recombinant EPO, should carefully evaluate the risks and benefits.

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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