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The Clinical Research on Serum Gastrin Changes with Colon Cancer Patients

Author: WangPeiJun
Tutor: YouShengYi
School: Tianjin Medical University
Course: Surgery
Keywords: colon adenocarcinoma gastrin receptor differentiation clinical research
CLC: R735.35
Type: Master's thesis
Year: 2011
Downloads: 54
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Abstract

Objective:Colon cancer is a common malignancy in the gastrointestinal system, in Western Europe, North America, higher rates of colon cancer in up to (35～50)/100 thousands, It is the third in malignant tumor..In our country, People’s lifestyle and dietary purpose、structure has changed with the development of economy, Colon cancer incidence and mortality increasing year by year.In recent years, It is a serious threat to the health of the people. studies found that serum gastrin and its receptor in colon cancer plays an important biological function in expression and in promoting colon cancer cell division, proliferation and differentiation, Studies have found that elevated serum gastrin in patients with liver metastasis of colon cancer incidence is not higher than in patients serum gastrin increased.Therefore, Study the relationship between serum gastrin and colon cancerwill further understanding of the impact factors of the development of colon cancer, and clinical treatment in their new theoretical basis.Serum gastrin in patients with colon cancer is cancer tissue secretion or from the gastrointestinal tract gastrin G cells is unclear. We have 30 cases of (?)olon cancer patients studied, the level of preoperative and postoperatrve serum gastrin determination to further understand the relationship between colon (?)nicer and serum gastrin.Methods:We selected 30 cases patients in tianjin medical univers(?)ty general hospital colon cancer patients in hospital surgery.From October 2009 to December 2011 as Study GroupSelect Another 15 cases of colon polyps (outpatient)and 15 cases of thyroid patients before (except for thyroid cancer patients) as the control group preoperative fasting gastrin clinical control study.According to the Without obstruction clinical manifestations divided into obstruction type and no obstruction type detereminted gastrin horme.To understanding of intestinal factors on the impact of serum gastrin Determination of the 30 cases of colon cancer patients changes on serum gastrin 1,3,7 days and preoperative, Retrospective analysis and contrast the 20 patients with non-obstructive 1,3,7 days the change after operation in serum gastrin. 10 cases of intestinal obstruction in patients with preoperative.According to whether do the tumor resection operation is divided into Tumor excision group and with tumor group. Retrospective Comparative analysis of residual tumor tissue effects on serum gastrin.Histopathological types report are adenocarcinoma. According to different differentiation, adenocarcinoma is divided into high differentiated adenocarcinoma, moderately differentiated adenocarcinoma, low differentiation and mucus adenocarcinoma, Retrospective analysis of the tumor resection group,20 patients with non-obstructive preoperative and postoperative day 7 serum gastrin changes. Patients after a detailed inquiry history, Preoperative long-term continuous (＞2 years) oral calcium channel blockers 6cases and never take Calcium channel blockers 10 cases, To recognize the changes in preoperative serum gastrin determination and understand the calcium channel blocker effects on serum gastrin.Serum gastrin detection using radiation immune analysis, Extracted peripheral venous blood 3.0ml in the morning, put into a test tube, In 3000 circle per minute about 5-6minutes.Let it into a 20C°froze preserving centrifugal ticked determined by the Tianjin Medical University Hospital determination of special inspection centers.Results:1.Contrary colon cancer 90.69±31.13pg/ml preoperative average, Colon polyps average gastrin level patients48.67±8.56pg/ml、Patients with nodular serum gastrin average 29.87±4.74 pg/ml,Serum gastrin was significantly higher in patients with colon cancer,Both have significant difference (P＜0.05).2. The no obstruction type patients gastrin meal before the average for 74.95±22.31 pg/ml, obstruction in a group of patients for 122.2±20.48 pg/ml, But the two groups was not significant (P＞0.05).3. Group of non-obstructive tumorColon cancer patients 3,7 days after surgery compared with preoperative serum gastrin was significantly reduced and have statistical difference (P＜0.05).In obstructive patients, the tumor resection group, 1,3,7 days after surgery compared with preoperative serum gastrin was significantly lower statistical significance (P＜0.05). Tumor group with preoperative and postoperative serum gastrin 1,3,7 day have significant difference compared (P＜0.05).4.Non-obstructive group of well-differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma, mucinous carcinoma compared with the preoperative serum gastrin decreased, there was statistically significant (P＜0.05), compared with patients in each group no statistical significance (P＞0.05).5.Preoperative long-term continuous (＞2 years) oral calcium channel blockers in patients with non-obstructive and never taking calcium channel blockers in patients with non-obstructive preoperative serum gastrin was not significant (P> 0.05).Conclusion:1. This study demonstrated significantly higher serum gastrin in patients with colon cancer and colon polyps and have statistically significant (P＜0.05), and Wong similar results. Prompted the development of colon cancer affect serum gastrin levels.2. obstructive colon cancer compared with non-obstructive colon cancer patients with preoperative higher serum gastrin, but not statistically significant (P＞0.05), Obstruction factors prompted the serum gastrin secretion in patients with colon cancer whether the impact of further study.3. Group of non-obstructive tumor Colon cancer patients 3,7 days after surgery compared with preoperative serum gastrin was significantly reduced and have statistical difference (P＜0.05).In obstructive patients, the tumor resection group, after surgery compared with preoperative serum gastrin was significantly lower statistical significance (P＜0.05). Tumor group with preoperative and postoperative serum gastrin 1,3,7 day was no significant difference compared (P＞0.05). Further confirmed as part of colon cancer serum gastrin secretion4. Colon tumor resection group was lower than the first 3,7 days of preoperative serum gastrin, there was a significant difference (P＜0.05). In obstructive patients, serum gastrin with tumor group was compared with the tumor resection group were significantly different (P＜0.05), tumor resection group was lower than the preoperative serum gastrin were significantly different (P＜0.05), with the tumor group was compared with the preoperative serum gastrin was no significant difference (P＞0.05). Further suggest elevated serum gastrin in patients with colon cancer may be secreted from colon cancer.5. Experimental studies have reported that calcium channel blockers can inhibit the formation of gastrin, thereby inhibiting the growth of colon cancer. In this study, patients with oral calcium channel blockers and calcium channel blockers have never taken before surgery in patients with no significant difference in serum gastrin (P＞0.05). Clinical variability due to the larger, needing further study.

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