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Analysis of the CYP2C19 Genetic Polymorphism in Uigur and the Association with Effects of Escitalopram

Author: AnZhiGuo
Tutor: YiZuoZhong
School: Xinjiang Medical University
Course: Psychiatry and Mental Health
Keywords: CYP2C19 Gene polymorphism Escitalopram Efficacy
CLC: R749.41
Type: Master's thesis
Year: 2011
Downloads: 64
Quote: 0
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Abstract


Objective: To investigate Uygur patients with depression CYP2C19 polymorphism Distribution and escitalopram antidepressant efficacy of the relationship between the individual to guide clinical medicine . Methods: 36 cases of gene chip technology meet CCMD-3 depressive episodes in patients with CYP2C19 genotype Uygur frequency analysis , and then give escitalopram 10-20mg / d treatment , with Hamilton Seoul depression scale (HAMD ) assessed the clinical efficacy of drugs with side effects scale (TESS) check the patient for adverse drug reactions , drug efficacy comparison between different genotypes differences. Results: Xinjiang Uygur population homozygous extensive metabolizers frequency of 61.11% , heterozygous extensive metabolizers frequency of 33.34% , poor metabolizer genotype frequency was 5.56% . Heterozygous extensive metabolizers group depression escitalopram general use after 1 week oral treatment HAMD score reduction was significantly higher than homozygous extensive metabolizer group , the difference was statistically significant (T = 5.526, P lt; 0.05) ; homozygous extensive metabolizer group , heterozygous extensive metabolizers and poor metabolizers group of patients with depression group after 1 week of treatment response rate was 31.81% ( 7 / 22 cases ) , 75.00% ( 9 / 12 cases ) and 100% ( 2 / 2 cases ) , homozygous extensive metabolizers group compared with the other two groups was significant difference (P lt; 0.05). Conclusion : The Xinjiang Uygur population CYP2C19 allele frequencies vary considerably compared with the Han people , poor metabolizer frequency much lower than Han population . CYP2C19 gene polymorphism with escitalopram association of drug efficacy . CYP2C19 gene polymorphism with escitalopram adverse drug reactions are associated. Clinically, patients with CYP2C19 genotype by testing to determine the speed of drug metabolism in patients with type , a reasonable dose adjustment is to improve drug efficacy and reduce adverse drug reactions and effective way.

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CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Affective psychosis > Manic depression ( bipolar disorder)
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