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Preventve Effect of Adenosine Triphosphate Magnesium Chlorid on Spinal Cord Ischemia Reperfusion Injury in Rabbits

Author: YinYan
Tutor: PuZhiGang
School: Yanbian University
Course: Surgery
Keywords: Rabbits Adenosine Triphosphate Magnesium Chlorid Spinal Cord Injury Ischemia Reperfusion
CLC: R651.2
Type: Master's thesis
Year: 2008
Downloads: 16
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Abstract


Objective:To evaluate the efects and possible mechanism of ATP-Mgcl2 on spinal cord ischemic injury in rabbits.Methods:The model of spinal cord ischemia-reperfusion in rabbits was established according to the description of Tetik.30 rabbits were randomly divided into sham operation group（A） ischemia-reperfusion group（B） and ATP-Mgcl2 group（C）.In group B and C,the infrarenal aorta was clamped for 40min followed by 48 hours reperfusion.ATP-Mgcl2（4ml / kg·h） was injected 10min before clamping in group C,and 0.9%Saline was used as a control in the other groups.The plasma concentrations of Maleic Dialdehyde（MDA）, Superoxide Dismutase（SOD）,were assayed before clamping（C0）,before unclamping (C40),and at 1 hour（R1） after unclamping.After operation,the neurologic out comes were evaluated by blind method.The morphology of the spinal cord was observed.Results:（1）The concentrations of MDA after ischemia-reperfusion in group B were increased significantly compared with those before clamping and those in group A（P＜0.01）,which in group C were lower significantly than those in group B（P＜0.05）,but not in group A.（2）The activity of SOD after ischemia-reperfusion was lower significantly in group B than that before clamping and that in group A（P＜0.01）,which was higher significantly in group C than that in group B（P＜0.05）,but no in group A.（3）The ratio of paralysis in group C was lower significantly than that in group B with a high neurologic score（P＜0.01）.（4）In group B,more pathological changes and a greater number of neuronaldeath were seen in group B,which was only occasionally in group C.Conclusion:The results suggest that ATP-Mgcl2 may reduce spinal cord injury and preserve neurological function in transient spinal cord ischemia in rabbits.

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CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Spinal cord
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