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Objective To investigate the pretreatment Ganlixin the repolarization after cardiac surgery and mechanisms . Methods 60 patients with rheumatic valve disease patients , ASA II to level III , elective cardiopulmonary bypass ( cardiopulmonary bypass , CPB ) downstream mitral valve replacement and random divided into Ganlixin group and control group , 30 cases in each group . The sequence intubation , Ganlixin group 100ml of 10% glucose plus Ganlixin 2.5mg/kg intravenous infusion of the control group, 100 ml of 10% glucose intravenous infusion into the liquid in both groups after induction of anesthesia to the period before skin incision 20min within the pump end . In the preoperative and postoperative 1d , 3d after recording synchronous 12-lead ECG , determination of QT dispersion ( QTd ) and QT dispersion school positive ( QTcd ) Another respectively after induction of anesthesia (T1), aortic cross-clamping after 15 min ( T2 ) , 15 min after aortic ( T3 ) , 2 h ( T4 ) , 24h ( T5 ) time points , venous blood samples by radioimmunoassay of serum calcitonin gene-related peptide ( CGRP ) , endothelin -1 ( ET - 1 ) . Ventricular arrhythmias observed within 7 days after the occurrence . After the two groups QTd and QTcd of compared with the preoperative significant increase ( P < 0.01 ) , postoperative 1d, the postoperative Group 3d Ganlixin QTd and QTcd compared with the control group was significantly shorter ( P < 0.05 ) ; aortic cross-clamping and the main artery open after the two groups of patients within 24 hours of CGRP level induction of anesthesia was significantly higher ( P lt ; 0.01 ) , and Ganlixin group was significantly higher than that in the control group ( P < 0.05 ) ; ET-1 , two groups of aortic cross-clamping after than those after induction of anesthesia decreased significantly ( P lt ; 0.01 ) , T1 , T2 point in time between the two groups showed no significant difference ( P GT ; 0.05 ) , two groups of patients within 24 hours after aortic ET-1 gradually increased , T4, T5 were significantly higher than the level of induction of anesthesia ( P lt ; 0.01 ) , the aortic opening up within 24 hours Ganlixin group was significantly lower than the control group ( P < 0.05 ) . The incidence of postoperative ventricular arrhythmia within 7 days no significant difference ( P gt ; 0.05 ) The conclusion Ganlixin pretreatment reduce cardiac surgery after myocardial repolarization abnormalities , has a protective effect on myocardial ischemia -reperfusion injury may be associated with cardiac ischemia and reperfusion of plasma CGRP and reduce the reperfusion period plasma ET-1 concentration no significant effect on postoperative ventricular arrhythmias .
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