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Objective: To investigate the N-acetylcysteine ??(NAC) on liver ischemia -reperfusion injury (HIRI) protective effect and mechanism METHODS: 40 cases of liver surgery patients need to Pringle , were randomly divided into two groups : (1) A group : ( blank control group , n = 20) surgery using saline ; (2) B (experimental group , n = 20 ) : intraoperative intravenous infusion NAC 150mg/kg . Pringle respectively (T0), Pringle 30min (T1), Pringle 1h (T2), 6h (T3), 24h (T4) after the opening of the central vein blood testing patient plasma malondialdehyde (MDA), superoxide dismutase ( SOD ) , nitric oxide (NO) and tumor necrosis factor -α (TNF-α) concentration levels . While observing the changes in patients at each time point , alanine aminotransferase (ALT) and aspartate aminotransferase (AST) . Results of surgery time : between the two groups , no difference in the amount of bleeding and the blocking time . The two groups of patients at T0 after each point in time , ALT , AST , MDA , SOD , NO , TNF -α concentrations compared with T0 differences were statistically significant ( P lt; 0.05 ) , elevated ALT and AST at T2 highest (P lt; 0.01), and the other indexes are T3 was highest (P lt; 0.01). Group B trend lower in group A , and the difference was statistically significant ( P lt; 0.05 ) . Conclusion: The intraoperative intravenous infusion of N-acetylcysteine ??, can significantly reduce the degree of hepatic tissue damage after ischemia-reperfusion and its mechanism of scavenging oxygen free radicals , increase the concentration of NO , inhibition of the inflammatory response . The experimental group has a protective effect on the liver , safe and effective clinical applications .
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