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Background and Purpose: Ischemic stroke is a serious harm to human health, quality of life and the life of one of the major diseases, is the obstacle to the blood supply of the brain caused by a variety of reasons, the local brain tissue irreversible damage, leading to brain tissue ischemic, hypoxic necrosis, not only can cause a variety of neurological dysfunction, and a huge burden to individuals, families and society. Its early diagnosis, preventive measures, the best treatment options and assess prognosis has important significance. Cystatin C (CysC) in recent years found a protein in vivo inhibition of cathepsin strongest, and its interaction with cathepsin keep the artery intima extracellular matrix deposition and degradation of the dynamic balance, once Both imbalance in atherosclerosis has started on the basis of the process of accelerated atherosclerosis. The purpose of this study is to investigate the cystatin C in ischemic stroke, and ischemic stroke risk factors, to assess whether cystatin C can for the early diagnosis of cerebral infarction, prognosis, provide experimental basis for clinical intervention value. Methods: This study from December 2009 to March 2011, the First Affiliated Hospital of Shantou University Medical College Department of Neurology, hospitalized patients randomly selected 115 patients with acute cerebral infarction patients for the experimental group and 110 cases of patients with cerebral infarction the control group underwent the head the MR / CT, carotid intima-media thickness detection, Cys c, LDL, Lp (a), HCY, UA, HbA1c, fructosamine imaging or laboratory tests, and collect relevant clinical data, the application SPSS 17.0 software for statistical analysis, cystatin C in order to understand the relationship between cerebral infarction. Results: 1. Serum Cys C levels in patients with acute cerebral infarction group than the normal control group, both significant, P lt; 0.001 univariate logistic regression of cerebral infarction in this group of risk factors analysis found that age, Cys C, HCY, type 2 diabetes (HbA1c, fructosamine), smoking, alcohol consumption, hypertension and carotid artery intima-media thickening of the risk factors for cerebral infarction, serum Cys C levels significantly statistically significant, P lt; 0.001 to filter out the risk factors in the univariate logistic regression analysis (type 2 diabetes optional multifactorial HbA1c representative) non-conditional logistic regression analysis, the results show that serum Cys C level statistics significance (P = 0.697, OR is 0.552); Cys C is one of the risk factors of cerebral infarction, but not an independent risk factor. 4 covariance analysis adjusted for age, uric acid, LDL, Lp (a), HCY, HbA1c and fructosamine and other factors CI group and the control group, serum Cys C levels were not statistically significant (P = 0.875), further instructions The Cys C under the combined effect of the above factors lead to cerebral infarction. 5 age stratified analysis showed that the young and the elderly group (aged 60 to 74 years old) and middle-aged (60 years of age) was statistically significant, P values ??were 0.017 CI group and control group comparison of the level of serum Cys C, 0.030; elderly group (older than 74 years old) level of serum Cys C values ??of CI group and the control group compared with the other two groups increased, but the contrast between the two was not statistically significant, P = 0.459. 6. serum Cys C levels and brain imaging lesion severity (grouped into normal group, lacunar infarction group and cerebral infarction group) was statistically significant in the univariate analysis of variance, P = 0.001, three groups between LDS inspection were statistically significant. Serum Cys C levels of homocysteine ??moderately positive correlation (r = 0.529, P lt; 0.001), and age (r = 0.293, P lt; 0.001), uric acid (r = 0.272, P lt; 0.001 ) Low positively correlated with HbA1c, fructosamine, LDL and LP (a) is not relevant; 8. serum Cys C regression equation: Cys C = 0.025 * HCY 0.008 * Age 0.001 * UA 0.156 9. cystatin C The area under the ROC curve was 0.624, P = 0.034, a sensitivity of 0.420, specificity of 0.875. Conclusion: 1. Patients with acute cerebral infarction, serum Cys C levels than normal control group significantly increased as the detection of one of the indicators of the acute phase; the acute phase serum cystatin C increases cerebral infarction one of the risk factors, but it is not an independent risk factor, due to the imbalance of cystatin C with age, UA, Cys C, HCY, type 2 diabetes (HbA1c, fructosamine), smoking, alcohol consumption, hypertension interaction, and other risk factors caused by the incidence of cerebral infarction. Serum cystatin C levels in patients less than 74 years old cerebral infarction group compared with the normal control group was significantly higher cystatin C as a 74-year-old crowd cerebral infarction detection indicators. Serum Cys C levels and the extent of damage of the brain imaging showed a positive correlation can be used for the detection and prognosis of the severity of the discrimination, the higher the level of serum cystatin C, the more serious the injury of brain tissue; 5. Levels of serum Cys C homocysteine, age, and uric acid, and the three have a linear relationship. 6 cystatin C as a diagnostic indicator of cerebral infarction, specificity, second only to head the MR than HCY, UA, IMT.
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