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Impaired Objective To study glucose regulation (IGR) combined with non -alcoholic fatty liver disease (NAFLD) serum leptin levels to explore the relevance of leptin and insulin resistance (IR) . Methods IGR fatty liver in 58 cases , including impaired fasting glucose (IFG) , 28 cases (IFG FL group ) IFG combined with impaired glucose tolerance (IGT) 30 cases (IGT FL group ) . The IGR with fatty liver were 63 cases , of which , IFG31 cases ( IFG NAFLD group ), IFG IGT32 cases of the (IGT NAFLD group ) . 30 cases of healthy control group (NC group ) . Measurement group fasting glucose , insulin , liver function , blood lipids , leptin , measurement of height, weight, waist and hip circumference , calculation of the homeostasis model assessment insulin resistance index ( HOMA - IR) . Explore with NAFLD and glucose metabolism disorders, changes in serum leptin levels and IR -related parameters in that body mass index (BMI), waist -hip ratio (WHR), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C ) , low-density lipoprotein cholesterol (LDL-C) correlation . Results ① IGR group WHR, FPG, HOMA-IR was significantly higher (P lt; 0.05). ② IFG NAFLD group with IFG compared to the FL group , serum leptin levels significantly increased ( P lt ; 0.05) : IGT NAFLD group with IGT FL compared leptin levels were significantly higher ( P lt; 0.05 ) . ③ The IGR and IGR with NAFLD group serum leptin and BMI, WHR, TG significantly positively correlated with HDL significantly with negative correlation , adjusted for age , gender, BMI after leptin and TG , LDL , HOMA-IR was positively correlated with HDL significantly with negative correlation . ④ multiple linear stepwise regression analysis showed that HOMA-IR, LDL have a significant impact on leptin . Conclusion ① IGR patients with high leptin , insulin resistance , increased after the merger NAFLD . NAFLD patients with glucose metabolism disorders , leptin levels increased further , IR heavier . High serum leptin , IR is closely related to jointly involved in the disorder of glucose metabolism and the occurrence of NAFLD development . ② IGR merger NAFLD , leptin , HOMA-IR with melon parameters than simply IGR group , to further prompt IGR merged NAFLD after aggravating IR . Early corrective lipid disorders , improve insulin sensitivity may improve metabolism , prevent the occurrence of the reversal of NAFLD , development .
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