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Treatment on NHL with Adoptive Immunotherapy: A Report of One Case and Review

Author: ChenYan
Tutor: LiuZhuoLa
School: Shanxi Medical
Course: Respiration within the science
Keywords: CIK cells DC-CIK cells NHL AIT
CLC: R733.1
Type: Master's thesis
Year: 2009
Downloads: 71
Quote: 0
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Abstract


Objective:To evaluate the safety and therapeutic effect of adoptive immunotherapy for non-Hodgkin’s lymphoma.Methods:A refractory and relapsed patient of non-Hodgkin’s lymphoma diagnosed pathologically with bone marrow infiltration was collected.With the treatment of R-CHOP regimen combined with allogeneic CIK cells and autologous DC-CIK,we observed the therapeutic effect.Results:1.The patient’s general condition improved significantly,living as a healthy people participating in work and daily life.2.Examination:After combined treatment,ultrasonography showed the tumor volume decreasing,although the lymph nodes grow up again during the maintenance therapy with AIT, the PET gave a negative result;Bone marrow biopsy indicated lymphoma cell disappeared;LDH and tumor-marker level was obviously lower than before;level descending;heteroploid cells disappeared;cytokine produced by Th1 cell increasing,ability of anti-cancer proving significance.3.Adverse effect:fever was the side effect during the therapy,other adverse effects were not observed.Conclusions:1.Adoptive immunotherapy has significant therapeutic effect to refractory and relapsed patients of NHL.2.Adoptive immunotherapy can improve the body’s immune function and enhance the anti-cancer effect.3.Providing a potent immune therapeutic strategy for tumor patients.

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CLC: > Medicine, health > Oncology > Hematopoietic and lymphoid neoplasms > Reticuloendothelial system tumors
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