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Objective:To investigate the levels and influential factors of serum glycoprotein (Krebs Von den Lungen-6，KL-6) and Lactate Dehydrogenase (LDH) in children with different severity of the viral pneumonia. Methods:from February 2010 to September 2010 at the First Affiliated Hospital of Xinjiang Medical University, according to the severity of disease,101 cases with viral pneumonia were divided into severe group (35 cases) and non-severe group (66 cases). The levels of serum glycoprotein KL-6 and LDH were determined, and the correlation were analyzed between the KL-6，LDH and WBC, the percentage of neutrophils, ESR, C reactive protein, CK, CK-MB, age, gender, nation, type of viral infection, severity of disease. Results:The levels of serum glycoprotein KL-6 and Lactate Dehydrogenase of severe group were significantly higher than those of non-severe group (P＜0.05); Simple linear correlation analysis showed that serum KL-6 had a positive correlation with LDH (P<0.05); multiple linear regression analysis showed that serum KL-6 had a significant correlation with severity, LDH, NE%, and associated meaningless WBC, ESR, CRP, CK, CK-MB, age, gender, nationality, and type of viral infection. Serum LDH correlated significantly with CRP, CK-MB, and associated meaningless the WBC, NE%, ESR, CK, age, gender, nationality, and type of viral infection. Conclusion:Serum KL-6 can be used as a sensitive and specific indicator to determine the severity of viral pneumonia. Thus it benefits for the therapy and good prognosis. Though serum LDH is not a specific index, but it can also reflect the degree of the disease changes.
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