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Objectives:To investigate the immune function changes,imaging changes and treatment of refractory mycoplasma pneumoniae pneumonia. Methods:The clinical data of 62 children with RMPP were reviewed from December 2008 to Dcember 2010 in our department.According to the randomized control study,the subjects were divided into two groups,corticosteroid group(31 cases) and the non-corticosteroid group(31 cases);In the same period 40 outpatient healthy children were considered as contol group;The clinical data was compared between the groups.Results:The levels of serum IgG and IgM, the ratio of CD3+/CD8+,from RMPP children, were significantly statistical higher than those from control group (P<0.05). The percentage of CD3+ cell, the ratio of CD3+/CD4+, the ratio of CD4+/CD8+,the expression of CD3+/CD25+ on T cell, from RMPP children,were significantly statistical lower than those from control group (P<0.05). The fever days,total hospital days, antibiotic use days, the number of repeated illness, from Hormone group children,were significantly statistical lower than those from non-hormone group(P<0.05). And the Hormone group children statistical rapidly improved clinical symptoms, imaging showed statisticaly fast improvement in lung disease(P<0.05).Conclusions:The pathogenesis of RMPP may be related to immune factor.Chest HRCT examination can help clear the extent of disease, objectively reflect the changes after treatment,and also can help forecast the outcome.Corticosteroids can significantly reduce the course and the recurrence.
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