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Oxidized low-density lipoprotein receptor 1 with intrahepatic cholestasis of pregnancy relationship

Author: RenSiJia
Tutor: WangDongMei
School: Xinjiang Medical University
Course: Obstetrics and Gynaecology
Keywords: Intrahepatic cholestasis of pregnancy Oxidized low-density lipoprotein Lectin -like oxidized low-density lipoprotein receptor 1 Low-density lipoprotein Total bilirubin
CLC: R714.255
Type: Master's thesis
Year: 2011
Downloads: 22
Quote: 0
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Abstract


Background: intrahepatic cholestasis of pregnancy (ICP) is a pregnancy and late complications peculiar is perinatal child morbidity and mortality one of the reasons. In this study, lipid metabolism disorders and ICP relationship start to study low-density lipoprotein (LDL) oxidation products of Ox-LDL and its specific receptor LOX-1 and ICP pathogenesis, diagnosis and treatment of ICP to try new method provides a theoretical basis. Objective: 1) investigate the oxidation of low-density lipoprotein (Ox-LDL) is involved in the pathogenesis of ICP. 2) hemagglutination hormone-like oxidized low-density lipoprotein receptor 1 (LOX-1) is involved in the pathogenesis of ICP. 3) Verify the existence of patients with ICP dyslipidemia. Method: 1) Select the First Affiliated Hospital of Xinjiang Medical University admitted 94 cases of obstetric intrahepatic cholestasis of pregnancy in patients hospitalized with the same period 94 cases were divided into normal control group and control group patients, ELISA assay and plasma oxidation expression levels of low-density lipoprotein; 2) Western blot were used to detect groups of patients placenta LOX-1 expression levels; 3) laboratory testing of plasma lipids, total bilirubin (TBIL) expression levels. Comparative analysis of clinical data between the two groups, oxidized low-density lipoprotein receptor 1, cholesterol, total bilirubin results. Results: 1) the case group and control group of patients aged 29.66-4.45 and 31.10-4.01 years old, the difference was not statistically significant (t '= 1.3668, P gt; 0.05); gestational weeks and were 37.34-1.80 37.96-1.51 weeks, the difference was not statistically significant (t '= 2.0413, P gt; 0,05). (2) the case group and control group Ox-LDL in plasma concentration of 22.87-10.84 ng / L and 24.77-20.90 ng / L, the difference was not statistically significant (t '= 0.7824, P gt; 0.05). 3) in case group LOX-1 expression in grayscale scanning is 1.55 ± 0.22, normal control group LOX-1 expression in patients with placenta grayscale scanning is 1.17-0.29, ICP placental LOX-1 protein levels higher than the normal control group, difference was statistically significant (t '= 10.1214, P lt; 0.05). 4) ICP group and control group were expressed in plasma TG level of 4.83-0.71μg / L and 2.27 ± 0.69μg / L, CHOL expression level of 8.28-1.11μg / L and 4.87 ± 0.76μg / L, LDL expression level of 4.42-1.59μg / L and 3.21-0.81μg / L, the case group was significantly higher than the expression level of the normal control group, the difference was statistically significant (t'TG = 25.0696, P lt; 0.05; t'cHOL = 24.5762, P lt ; 0.05; t'LDL = 2.5694, P lt; 0.05 ;); case group and normal control group expression levels of HDL were 1.08-0.26μg / L and 2.31 ± 1.26μg / L, the case group was significantly lower than normal levels of expression the control group, the difference was statistically significant (t '= 9.2692, P lt; 0.05); case group and control group TBIL expression levels in plasma were 16.21 ± 12.25μmol / L and 8.27 ± 2.81μmol / L, expression levels of the case group higher, the difference was statistically significant (t '= 6.1251, P lt; 0.05). Conclusions: 1) age and the incidence of gestational age has nothing to do with the ICP. 2) Ox-LDL is not involved in the pathogenesis of ICP that patients with ICP plasma ox-LDL levels are not elevated causes and antioxidants - elevated bilirubin. 3) LOX-1 involved in the pathophysiological process of pathogenesis of ICP. 4) confirmed dyslipidemia and ICP pathogenesis.

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CLC: > Medicine, health > Obstetrics and Gynaecology > Obstetrics > Pathological pregnancy ( abnormal pregnancy ) > Complications of pregnancy > Digestive and abdominal diseases
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