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Background: Inflammatory bowel disease (Inflammtory bowel disease, IBD), mainly including ulcerative colitis (Ulcerative colitis, UC) and Crohn's disease (Crohn's disease, CD) is a class of unknown etiology intestinal chronic unspecified dyspepsia, inflammatory disease, common in Europe and North America and other Western countries. Incidence in Asian countries is lower than in Western countries, but in the rapid growth of epidemiological reports more and more, especially some of the long-term follow-up study in Japan, South Korea, the disease incidence trends, clinical features With a deep understanding. The long-term follow-up study in this regard is still lacking, with IBD incidence increased, we study its epidemiology has become even more urgent, epidemiological information for us to look for its causes, characteristics and guidance Clinical treatment provide important information. Objective: To analyze the clinical data of the past 15 years in eastern China with ulcerative colitis (UC) and Crohn's disease (CD) patients understand the clinical epidemiology of inflammatory bowel disease (IBD) 15 features and treatment options trend. Methods: by the IBD database collected from January 1, 1995 to 2009 IBD inpatients diagnosed by Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine clinical data and analyzed retrospectively. IBD patients divided into four groups according to admission time and type: (A1 = UC, 2004, 1995; B1 group = UC, 2005 -2,009; A2 = the CD - 2004 1995; B2 = CD 2005 - 2009), the comparative analysis of the trends of the four groups of patients with clinical features and treatment options. Results: In 15 years, the Run Run Shaw Hospital diagnosed IBD patients hospitalized a total of 427 cases, which UC251, CD176 cases. IBD average admission constituted than in Group A 1910 x 10-6,15 years, an increase of 1.6 times for 1216 × 10-6, B group. A1 and A2 group average admission constitutes 833 × 10-6 and 383 × 10-6; the average hospitalized constitute of the B1 group and B2 group were 956 × 10-6 and 954 × 10-6. 15 years CD's admission constitutes an increase of 2.5 times, while UC increased by only 1.1 times. And constitute the admission of the 2009 CD ratio exceeds UC constitute the admission of the 2009 year CD than for 1313 × 10-6, UC 747 x 10-6 (P = 0.009 P lt; 0.01). UC is the average age at diagnosis was 47.53 ± 14.1 years, the male to female ratio of 1.04:1, the surgery rate, mortality rate, parenteral complication rates were 7.6%, 0.4% and 31.9%, family history of 0.4%. CD, the average age at diagnosis was 34.53 ± 13.4 years, the male to female ratio of 1.48:1, the surgery rate, mortality rate, parenteral complication rates were 18.4%, 0.9% and 45.5%, family history of 1.7%. 15 years, UC and CD patients with an average age at diagnosis, sex ratio, mortality, parenteral complications, family history, no significant difference (P gt; 0.05). Group B amino salicylic acid, corticosteroids, immunosuppressants and biologics applications than in group A (P lt; 0.05). Conclusion: Over the past 15 years, China's eastern region IBD admissions constitute a gradual growth than in the growth of the CD is particularly significant. But IBD age at diagnosis, sex ratio, family history, surgical rate, the death rate did not change. For the past five years, immunosuppressants and biological agents used in the gradually increasing.
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