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Objective in rabbits with acute pulmonary embolism (APE) model DSA, CTPA and the results were compared DEPI study on dual-source CT pulmonary angiography (CTPA) and dual energy lung perfusion imaging (DEPI) APE diagnosis of rabbit value. Methods 10 experimental rabbits, X-ray fluoroscopy to 4F catheter inserted via the right ventricle with bilateral pulmonary artery, and sizes of gel injected foam, APE establishing rabbit model, then underwent DSA and dual-source dual-energy CT lung perfusion imaging , rabbits were sacrificed for pathological anatomy examination. ① were calculated DSA, CTPA, DEPI rabbits APE diagnostic sensitivity and specificity, and compare the three methods (DSA, CTPA, DEPI) and pathological anatomy consistent results; ② rabbits were calculated and compared before and after embolization of RV / LV values. Results ① Compared with the autopsy results, DSA, CTPA and APE DEPI diagnostic sensitivity and specificity were 90.5% and 100%, 71.4% and 100%, 85.7% and 92.9%, kappa values were 0.884,0.667, 0.767, DEPI and DSA good consistency, CTPA consistency in general. DEPI on the performance of blue-black district embolism perfusion to reduce the area, the performance of non-embolic areas of normal perfusion area of red and yellow. ② rabbits before and after embolization largest two-chamber short axis diameter ratio (RV / LV) were significantly different (P lt; 0.05), after embolization rabbits RV / LV significantly higher than before embolization. Conclusion The dual source CT pulmonary angiography (CTPA) can better show lung anatomical information, dual energy lung perfusion imaging (DEPI) can better evaluate lung function information on the APE has important diagnostic value. Purpose of APE by dual-energy perfusion defect index, embolism Index and RV / LV three indicators correlation analysis shows DEPI in the evaluation of the severity of the feasibility of APE. The method has been APE dual source CT diagnosis of 24 cases, the use of Lung PBV software for data post-processing images obtained CT pulmonary angiography (CTPA), DEPI, were calculated for each patient perfusion defect index, embolism index and the maximum diameter of the minor axis dual-chamber ratio (RV / LV), using the Spearman correlation analysis method, and more serious and non-serious APE APE group group perfusion defect index, embolism Index and RV / LV. Results 24 cases of APE patients, severe APE 9 cases of non-severe APE 15 cases Severe perfusion defect index APE group, embolization Index and RV / LV, the median was 32.5% (15.0% -62.5%), 45.0% (27.5% -75.0%) and 1.16 (1.04-1.45), but not serious APE group perfusion defect index, embolism Index and RV / LV, the median was 12.5% (0-37.5%), 12.5% (2.5% -42.5%) and 1.03 (0.85-1.41), severe APE group of indicators higher than the non-serious APE group, there was significant difference between the two groups (P lt; 0.05). Correlation analysis showed that perfusion defect index and RV / LV and embolism index was positively correlated (r = 0.635, P lt; 0.05; r = 0.790, P lt; 0.05). Conclusion quantized dual energy lung perfusion evaluation method can better reflect the artery embolization regional distribution of pulmonary blood flow, perfusion defect index together with embolization index, RV / LV APE in the evaluation of severity is feasible.
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