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Association of Genetic Polymorphism in Phenylthanolamine-N-methyl Transferase with Essential Hypertension in Hunan Han Population

Author: ChenAn
Tutor: ZhangGuoGang
School: Central South University
Course: Internal Medicine
Keywords: Phenylethanolamine -N- methyltransferase (COMT) Essential hypertension Single nucleotide polymorphisms
CLC: R544.1
Type: Master's thesis
Year: 2009
Downloads: 17
Quote: 0
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Abstract


Background: Hypertension (Essential Hypertension, EH) is one of the most common cardiovascular disease is a major public health problem worldwide. Essential hypertension is a complex disease of genetic predisposition and environmental factors jointly decided. The crowd of 30 to 60% of blood pressure variation due to genetic factors. Hypertension genetic risk factors, they use a strategy of candidate genes, one of which is located on the 17th chromosome q21 position phenylethanolamine-N-methyl transferase (PNMT) gene is. PNMT is the end of catecholamine biosynthesis enzyme that catalyzes the norepinephrine generate adrenaline, the activity of norepinephrine and epinephrine levels can affect the body, so as to participate in the pathophysiology of hypertension process, so the encoding PNMT gene study one of the important essential hypertension susceptibility candidate genes. Abroad PNMT gene with essential hypertension susceptibility reported, but China has yet to see similar reports. Objective: To investigate phenylethanolamine-N-methyl transferase (PNMT) G-390A gene polymorphism and Hunan Han population with essential hypertension genetic susceptibility. Methods: Polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) analysis method, point PNMT gene PNMT G-390A gene in 400 patients with essential hypertension and 388 healthy people genotyping. The distribution of genotypes and A allele frequencies between the application χ ~ 2 test was used to compare group similarities and differences, and the to test different gender groups between genotype and A allele frequency distribution of the similarities and differences; application of non-conditional logistic regression analysis of risk factors correction determine the correlation relationship between PNMT genotype with essential hypertension genetic susceptibility; different genotype general application of the one-way analysis of variance test hypertension group and control group differences. Results: 1. Cases of hypertension group PNMT gene G-390A polymorphic loci GG, GA and AA genotype frequencies were 39.3%, 50.0% and 10.8% of the control group, the G-390A polymorphic loci GG, GA and AA genotype frequencies were 43.6%, 45.6% and 10.8%, respectively, and the distribution of genotypes were in Hardy-Weinberg equilibrium; genotype distribution between cases and controls was no statistically significant difference (p = 0.433); 2 cases of hypertension group - 390A allele frequency was 35.8%, the control group, 33.6% of the-390A allele frequency distribution was no statistically significant difference (p = 0.378) in cases of hypertension in the control group; Logistic regression analysis show , PNMT G-390A polymorphism has nothing to do with the risk of essential hypertension; stratified analysis by gender, men between the case and control groups PNMT G-390A genotype distribution has a statistically significant (p A allele frequency = 0.05), male patient group was significantly higher than that in the control group (p = 0.046); G-390A polymorphism genotype and allele frequencies between female patients and the control group no significant difference (p> 0.05). Conclusion: The genetic polymorphisms of PNMT G-390A may be related to the susceptibility of essential hypertension in Hunan Han population male.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
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