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Objective : To study the Uygur , Han population 5,10 - methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism in and predict Wei, Han population for adverse reactions after taking methotrexate differences . Methods: PCR -restriction fragment length polymorphism technique (PCR-RFLP) analysis of MTHFR C677T genotype in Xinjiang Uygur and 166 cases 134 cases Han population frequency distribution . Results: Xinjiang Han population MTHFR C677T genotype frequencies were C/C21.7%, C/T53.0% and T/T25.3%, Uygur was C/C16.4%, C/T80.6% and T / T2.96%, the difference was statistically significant (P lt; 0.05). Uighur men the genotype frequencies were 16.95% , 79.7% and 3.39% , women 9.1% , 88.0% and 2.67% (P gt; 0.05); Han males was 25.8 %, 47.1 %, and 27.1 for women 17.28% , 59.26% and 23.46% , the difference was not statistically significant (P gt; 0.05). Conclusion : The Xinjiang Uygur and Han Nationality MTHFR C677T genotype three CC, CT, TT distribution differences , all three genotypes did not differ between genders , and predict the clinical time if the same dose methotrexate and Han patients probability and extent of adverse reactions is higher in patients than Uygur . Meanwhile, after taking the same dose methotrexate in patients with MTHFR 677TT genotype probability of occurrence and extent of side effects is higher than MTHFR677CC/CT .
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