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Tanshinone Ⅱ A subarachnoid hemorrhage patients with plasma calcium and endothelin

Author: XuYingNan
Tutor: XueHongLi
School: Liaoning University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: TanⅡA sulfoacid natrium injection Cerebral vasospasm nimodipine injection Serum ET Serum ca2+
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 14
Quote: 0
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Abstract


Purpose:observe the activity of ET-1 and the dose of calcium ion influced by tanshinoneⅡA（TanⅡA）in clinical subarachnoid hemorrhage （SAH） patients,serum. evaluate the tanⅡA s,prevention and curation of cerebral vasospasm in SAH patients. to provide theory for cerebral diseases by tanⅡA in clinical application。Material and method:60 SAH patients divided by conscious disturbance or not ,test goup （tanⅡA sulfoacid natrium injection group）（conscious disturbance n=15, consciousness n=15） and control group （isotonic Na chloride group）（conscious disturbance n=15, consciousness n=15）, all groups were received treatment when occurred in 72h. control group received nimodipine injection. including nimodipine injection, test group also received tanⅡA sulfoacid natrium injection ,40-60mg q.d for 15 days, the whole course of treatment was 20 days. test the serum level of ca2+ and ET in first, third, and fourteenth days。Results:patients received 20 days treatment, test group have a low incidence and morality rate （t 4.5%）, comparing with the control group, the difference was siginificant（P<0.05）. the rehemorrhagia rate was 11.0% and 13.3%, there was no siginificant between the groups（P<0.05）. the ET level in test group was greatly less than the control group（P<0.05 or P<0.01）. the ca2+ level in test group was greatly higher than the control group（P<0.05 or P<0.01）.Conclusion:anⅡA sulfoacid natrium injection may has a reliable effect for prevention and curation of cerebral vasospasm in SAH patients, it can accelerate the rehabilitation of nerve without increasing the risk of rehemorrhagia. the decreasing level of ET-1 maybe one of the mechanisms.

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