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Objective: To filter out multiple injuries mainly affect chest trauma patients with risk factors for infection, and explore the first day after injury, plasma IL-1β, IL-4, IL-8, LL-10, TNFα, IFN-γ increased amplitude and late concurrent infection. Methods: Chongqing Emergency Medical Center, Daping Hospital, Third Military Medical University from January 2006 to June 2008 where 230 cases of chest trauma-based cases of multiple trauma, hypothermia gt; of 38.5 ℃ lt; 36.5 ° C, The white blood cell count gt; 10 × 109 / L or lt; 4 × 109 / L, imaging studies and drainage fluid culture positive results divided into concurrent infection group (91 cases) and non-infected group (139 cases). 32 possible risk factors for multifactorial study cohort, multivariate logistic regression analysis, and then P lt; 0.05 univariate analysis. Using enzyme-linked immunosorbent assay (ELISA) in patients with injuries one day after the plasma IL-1β, IL-4, IL-8, LL-10, TNFα, IFN-γ content, and the comparison between the two groups increased amplitude. Results: (1) multiple trauma patients with chest trauma-based relative risk of infection with the following factors: multiple organ dysfunction score (MODS score) (OR: 7.371; 95% CI :2.781-19 .536; P lt; 0.0001 aspiration (OR: 9.930; 95% CI :1.919-51 .371; P = 0.0062), head injury), the number of operations (≥ 2) (OR: 5.352; 95% CI :1.956-14 .643; P = 0.0011) (OR: 3.664; 95% CI :1.261-1 .646; P = 0.0171), pancreatic injury (OR: 11.991; 95% CI :1.374-104 .665; P = 0.0246), renal injury (OR: 5.815; 95% CI 1.235- 27.372; P = 0.0259), gastrointestinal injury (OR: 10.671; 95% CI :2.470-46 .113; P = 0.0015); (2) MODS scores, number of operations, head injury, pancreatic damage, kidney damage, stomach intestinal damage was significantly higher than that of non-infected group (3.11 ± 1.79 vs 1.04 ± 1.32,1.61 ± 0.72 vs 1.15 ± 0.54,32.97% vs 9.41%, 7.72% vs 0.71%, 13.18% vs2.14%, 10.98% vs2.88 %) (P lt; 0.05). (3) the the infected plasma IL-1β, IL-4, IL-8, TNFα, IFN-γ was significantly higher than that of non-infected group (1501.19 ± 2186.06 pg / ml vs 1127.07 ± 1755.43 pg / ml and 52.55 ± 82.55 pg / ml vs 26.36 ± 18.18 pg / ml, 38783.49 ± 17869.41 pg / ml vs 26165.32 ± 15306.77 pg / ml, 5251.46 ± 5554.46 pg / ml vs 5101.83 ± 4357.64 pg / ml, 181.97 ± 276.18 pg / ml vs 34.89 ± 108.42 pg / ml) (P lt; 0.05). Infection group IL-10 compared with the uninfected group (93.57 ± 100.40pg / m vs 55.14 ± 81.92 pg / ml), the difference was not statistically significant (P gt; 0.05). Conclusion: The higher mainly of chest trauma patients with multiple injuries MODS score, the more severe head injury and abdominal trauma, coma caused by aspiration, the more the number of operations performed, the greater the likelihood of concurrent infections; plasma IL-one day after the injury 1β, IL-4, IL-8, TNFα and IFN-γ levels increased range can be used as reference predict patients late whether concurrent infection.
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