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Benign and malignant thyroid nodules sonographic features and Logistic Regression Analysis

Author: YangTian
Tutor: CheYing
School: Dalian Medical University
Course: Medical Imaging and Nuclear Medicine
Keywords: Ultrasonography Thyroid nodules Logistic Model
CLC: R445.1
Type: Master's thesis
Year: 2011
Downloads: 33
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Abstract


Objective: To analyze benign and malignant thyroid nodules sonographic features, and filter out most diagnostic significance of sonographic features in order to improve the diagnosis of benign and malignant thyroid nodules rate. Methods: 63 patients of the 100 studied thyroid nodules, nodules OK for all grayscale and color Doppler ultrasound scan, all cases were confirmed by pathology. Statistical comparison of the sonographic features of thyroid nodules differential diagnosis of benign and malignant, calculate the sonographic features of benign and malignant thyroid nodules diagnostic sensitivity and specificity; Logistic regression analysis selected the most diagnostic significance pan Figure features. Results: The diagnosis of benign and malignant thyroid nodules meaningful sonographic features include shape, boundary, Halo, internal echo, echo level, echo uniform, microcalcifications, swollen lymph nodes, blood flow distribution patterns, blood vessels form. Two-dimensional gray-scale ultrasound shows: malignant thyroid nodules showed irregular (76.09%), the boundary is not clear (84.78%), peripheral silent halo (80.43%), the internal solid echo (86.96%), the echo level hypoechoic (89.13%), echo uneven (82.61%), visible microcalcifications (60.87%), cervical lymphadenopathy (58.70%); Color Doppler ultrasound showed blood flow mainly internal (60.87%) , irregularly shaped blood vessels (65.22%). The sonographic features of malignant thyroid nodules diagnostic sensitivity and specificity are: irregular (76.09%, 79.63%), the boundary is not clear (84.78%, 85.19%), peripheral silent halo (71.74%, 62.96 %), the internal solid echo (86.96%, 59.25%), hypoechoic echo level (89.13%, 59.26%), echo uneven (82.61%, 55.55%), microcalcifications (60.87%, 92.59%), neck lymph nodes (58.70%, 92.59%), the internal flow-based (60.87%, 83.34%), irregular-shaped blood vessels (65.22%, 92.59%). Considering the variety of sonographic features, ultrasound diagnosis of benign and malignant thyroid nodules sensitivity, specificity and accuracy were 84.78%, 77.78%, 81.00%. Logistic regression analysis screened out through most diagnostic significance of sonographic features, including: borders, microcalcifications, blood vessels and blood flow distribution shape. Conclusion: Ultrasound diagnosis of benign and malignant thyroid nodules a very effective way to check. Borders, microcalcifications, blood vessels and blood flow distribution shape diagnosis of benign and malignant thyroid nodules important basis.

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CLC: > Medicine, health > Clinical > Diagnostics > Diagnostic Imaging > Ultrasonic diagnosis
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