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Association Study on SNPs of Toll Like Receptor 9 Gene and Environmental Factors with Systemic Lupus Erythematosus in Anhui Han Population

Author: XuChangJuan
Tutor: YeDongQing
School: Anhui Medical University,
Course: Epidemiology and Biostatistics,
Keywords: Systemic Lupus Erythematosus Toll-like receptor 9 Single nucleotide polymorphisms Exon region Promoter region Environmental Factors Nuclear Family Gene - environment interactions
CLC: R593.241
Type: Master's thesis
Year: 2009
Downloads: 113
Quote: 1
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Abstract


Objective To analyze Anhui Ji Han population SLE families TLR9 gene single nucleotide polymorphisms, explore TLR9 gene polymorphism on susceptibility to SLE, SLE patients with normal incidence of SLE compatriots as a control analysis of possible environmental risk factors. Methods pedigree collection methods to collect 74 nuclear families, 77 cases of confirmed SLE famous faculty members and 211 blood samples and questionnaire data, salting extract genomic DNA, using restriction fragment length polymorphism (restriction fragment length polymorphism, RFLP) for SNPs detection using FBAT software for family-based association analysis, analysis of TLR9 gene polymorphism and SLE relationship. Using conditional logistic regression analysis method to analyze the possible environmental factors and association of SLE and the interaction of genetic and environmental factors affecting the incidence of SLE. The results of the study pedigrees, TLR9 gene rs352140 genotype CC, CT and TT frequencies were 20.8%, 61.0% and 18.2%, rs5743836 locus polymorphism does not exist, all for the TT genotype. Locus analysis showed that the dominant model, rs352140 T allele associated with the pathogenesis of SLE (Z = 2.357, P = 0.018402), but in the additive model and recessive model no relevance. Genotype analysis showed, CT genotype associated with the pathogenesis of SLE (Z = 2.004, P = 0.045067). )]; multivariate analysis, after adjusting for gender, noise, allergies and other factors, TLR9 gene rs352140 SNP loci did not enter the model, suggesting that TLR9 gene rs352140 SNP loci may not be an independent risk factor for the pathogenesis of SLE; gene environment interaction analysis showed that in addition to allergies * rs352140 into the model, the other effects of the interaction term was not statistically significant, suggesting that the selected candidate with a history of allergies there is a positive interaction between genes. Conclusion Anhui Ji Han population TLR9 gene second exon rs352140 loci may be associated with genetic susceptibility to SLE, but TLR9 gene promoter region rs5743836 locus polymorphism does not exist; variety of environmental factors associated with the pathogenesis of SLE, and TLR9 gene rs352140 polymorphism loci can increase the risk of allergies occur SLE.

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CLC: > Medicine, health > Internal Medicine > Systemic disease > Autoimmune diseases > Autoimmune diseases, connective tissue disease > Lupus erythematosus > Systemic lupus erythematosus
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