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Quality Assessment of Radix mode antler other four commodities

Author: ZhangYang
Tutor: LiFeng
School: Liaoning University of Traditional Chinese Medicine
Course: Pharmacognosy
Keywords: Cornu Cervi Pantotrichum Gecko Zaocys Agkistrodon assaying evaluation quality Grey correlation degree
CLC: R282.7
Type: Master's thesis
Year: 2008
Downloads: 223
Quote: 3
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Abstract


Cornu Cervi Pantotrichum Gecko Zaocys and Agkistrodon are all traditional valuable Chinese crude drug . Cornu Cervi Pantotrichum is not a calcif ped-horn of stag Cervus nippon Temminck or Cervus elaphus Linnaeus. Gecko is a dry body of Gecko chinensis division animal. Zaocys is a dry body of Colubridae animal. Agkistrodon is a dry body of Agkistrodon acutus（Guenther）. The effect is the same as Zaocys.But To the present quality evaluation are seldom,caused the quality control and the evaluation system were having some flaws.This topic to beginned with the principal component analysis.The grey correlation pattern recognition was applied to systematic evaluate quality of the four crude drugs from different commodity areas. Meanwhile, correlation analysis were made that the content of total nucleside with others composition.For the establishing quality control method, it offered the simply and optimize target.Part One: The Study of QualityAccording to the feature of the main chemical composition of the four crude drugs. , and compared their contents: nuleside, phospholipid, polyamines, polysaccharede, protein and harmful elements: Cu, Cd, Pb, Hg, As, and then to reveal the interrelation and quality.The five composition of Gecko,Zaocys and Agkistrodon were analyzed for the first time.And optimize filt the influence factors to content of total-nuleside, put forward the content of hypoxanthine to mark content of total-nuleside,thus to simplyify the control target of them. Part Two: The Method Study of model to Evaluate QualityFor the first time, the grey pattern recognition was adopted to system evaluation the four commodity medicine. Meanwhile combine the application feature firstly, correlation analysis were made that the content of total nucleside with others composition in the four crude drugs ,and set up the regression equation which provided basis for quantitative correlation of chemical composition in the four crude drugs. To further institute the quality specification of the kind crude drugs provide the simplify the determination target.Part Three: The ConclutionThe content of the five main chemical composition from differet commodity areas were dfferent .Besides individual commodity medicinal substances,all the others content of harmful elementary are low to limit the amount to the green color trade trade export and import standard in plant amedica and preparation . The quantitative correlation equations of the five composition content are as follows Y=-1.8096X1+0.0113X2-0.0012X3+0.0289X4+2.6124 Y=-0.2022X1-1.4194X2-0.0428X3+0.1411X4+9.8295 Y=1.1192X1+0.2483X2-0.0582X3+0.0705X4-0.4247 Y=0.0846X1-0.8898X2-0.0728X3-0.0936X4+7.3199Y was total nucleoside the others are total phospholipids super-polysaccharide polyamine total protein content.From the equations,we could find the content of total nucleside and polyamine are all submitting negative correlation.We could put forward the total nucleside and polyamine as the simply quality contorl target.The grey correlatiom degree pattern was applied to evaluate quality of the four crude drugs from different species and collect places. The better crude drugs Cornu Cervi Pantotrichum was from Kaifeng ,the worst was Shenyang The better crude drugs Gecko was Taiyuan, the worst was Neimenggu. The better crude drugs Zaocys was Dalian, the worst was Liaoyuan. The better crude drugs Agkistrodon was Tunhua, the worst was Shanghai

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese herbal medicines > Various types of medicinal herbs
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