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The Relevant Research for Relationship between Human Cytomegalovirus Active Infection and Atherosclerotic Cerebral Infarction

Author: ZhangZuo
Tutor: ShenXueLi
School: China Medical University
Course: Neurology
Keywords: Atherosclerosis cerebral infarction human cytomegalovirus ELASA carotid
CLC: R743.3
Type: Master's thesis
Year: 2009
Downloads: 75
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Abstract


ObjectiveAtherosclerosis(AS) is regarded as the major pathological foundtion of cerebral infarction(CI),but clinical research finds that 30%～40%patients with atherosclerosis have not traditional dangerous factors such as hypertension,diabetes, blood liquid,cigarette and heredity.To investigate other risk factors of AS and atherosclerotic ischemic cerebrovasclar disease and develop intervetion measures correspondingly are drawing more and more attention in academic circles.Rcently, most researchers pay more attention to infection,especially the relationship between cytomegalovirus and atherosclerosis.But there are not more reports about the relationship.The relevant research for relationship between cytomegalovius and atherosclerotic ischemic stoke only put forward part of experiment basis until now., which still need plenty of case-control studies and related laboratory statistic to confirm.This purpose of study is to provide a further experiment basis so that we can investigate the relationship of active infection of human cytomegalovirus(HCMV) and occurrence and progressing of AS and atherosclerotic ischemic stoke.It will provide theoretical foundation for preventing atherosclerotic ischemic crerbrovascular disease due to infection of HCMV by application of antiviralsMethodsELISA was used for the detection of IgM antibodies against HCMV in serum of 85 patients with atherosclerotic ischemic stoke,compared with those in 77 patients with carotid atherosclerosis(CAS)and in 73 volunteers as normal control group(NC).Compared OD value and the positive rates of IgM antibodies with the control group. ResultsIn NC,CAS and CI groups,the OD value of anti- HCMV IgM is 0.60±0.05、0.81±0.07and 0.94±0.07 respectively,The OD value of HCMV IgM had statistical significant difference(F=7.281;P＜0.01) among three groups.;the positive cases of anti- HCMV IgM is 13、30 and 42 respectively,the positive rates of HCMVIgM is 17.8%、39.0%、49.4%respectively,The positive rate of HCMV IgM had statistical significant difference(X~2=17.376,P＜0.001) among three groups.Both have the same conclusion that the activities of HCMVIgM infection have relationship with atherosclerosis and cerebral infarction.Compared the CAS group with NC group,the positive rate of HCMV IgM had statistical significant difference(X~2=8.20,P＜0.01).It demonstrated that HCMV IgM had statistically association with incidence of CAS.To move forward a single step,odd ratio(OR) was calculated,OR=2.95 and its 95% confidence interval【1.39,6.27】。So to speak,HCMVIgM antibody positive group compared with HCMVIgM antibody-negative 2.95 times that of people have the possibility of occurrence of carotid atherosclerosis risk..Compared the CI group with NC group,the positive rate of HCMV IgM had statistical significant difference(X~2 =17.285,P＜0.001).It demonstrated that IgM anti-HCMV had statistically association with incidence of Stoke.To move forward a single step,odd ratio(OR) was calculated, OR=4.51,and its 95%confidence interval【2.16,9.40】。So to speak,HCMVIgM antibody positive group compared with HCMVIgM antibody-negative 2.95 times that of people have the possibility of occurrence of carotid atherosclerosis risk.Compared the CI group with CAS group,the positive rate of HCMV IgM hadn’t statistical significant difference(X~2=1.78,P＞0.05),which means the activities of HCMV infection between CI group and CAS group have similarity in the blood distributionConclusion1 Active infection of HCMV may be associated with Carotid Atherosclerosis2 Active infection of HCMV may be associated with atherosclerotic ischemic stoke.3 Active cytomegaloviral infection may be an independent risk factor for acute cerebrovascular affair.This could be used to explain why 40%of people without traditional atherosclerotic risk factors had developed atherosclerosis or stoke really.4 Clinical detection for HCMV IgM antibody could possibly provide information with regard to acute cerebrovascular disease and serve a monitoring indicatrix of antiviral drag treatment and prognosis.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
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