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The Effect of Fangxiaoling Capsule on the Apoptosis of Eosinophile Granulocyte and Tracheal Reconstruction in Lung Tissue of Bronchial Asthmatic Rats Model

Author: Wei
Tutor: ZhouZhaoShan
School: Shandong University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Anti - roaring Ling Capsule Asthmatic rats Airway inflammation Eosinophils Airway remodeling
CLC: R285.5
Type: Master's thesis
Year: 2009
Downloads: 42
Quote: 1
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Abstract


Objective: To investigate the anti - roaring Ling Capsule eosinophils in the lung tissue of asthmatic rats (EOS) and airway remodeling in bronchial asthma and chronic airway inflammation hypothesis , which clarify the anti- whooping Ling Capsule mechanism against the disease provide experimental basis for clinical application of anti - whooping Ling capsule . Methods: 84 Wistar rats were randomly divided into normal control group , model group , dexamethasone group , low dose group of anti- roaring Ling Capsule , anti- roaring Capsules dose group , anti- roaring Capsules dose group , anti- whooping Ling Capsule high dose group ( n = 12 ) , OVA sensitized excited establish rat model of asthma , to the appropriate drug intervention , the general condition of the rats , observed and recorded 8 weeks after treatment , the light microscope rats pathological changes of the lung tissue , TUNEL method EOS apoptosis in lung tissue , apoptotic regulators Fas and Bcl-2 protein expression of TGF -β1 in quantitative lung tissue immunohistochemistry assay in lung tissue EOS Ⅰ , Ⅲ type collagen expression quantitative . Relevant experimental data using SPSS10.0 statistical software for statistical analysis. Results: The the rat general condition and tissue pathological changes suggestive of asthma model copied successfully , compared with normal control group , model control lung tissue EOS infiltration increased, decreased apoptosis , low expression of the EOS -apoptotic gene Fas and Bcl-2 TGF-β1 is highly expressed in the highly expressed in lung tissue , increased deposition of collagen type III protein . Improve the general condition of asthmatic rats , pathological changes and EOS infiltration and the role of airway remodeling results in the treatment groups with the model group are also significant differences ( p lt; 0.05 ) , comprehensive comparison of the ground plug the betamethasone group treatment of the role of the most significant anti- roaring capsules dose group with which close the high doses of anti- roaring Ling Capsule , middle dose group 2 followed by anti- roaring Ling Capsule weakest role of the low-dose group . Conclusion : ① anti whooping Ling Capsule can effectively alleviate asthma rat model of clinical manifestations and airway inflammation , its mechanism of action is to : Fas gene expression by raising and lowering of Bcl- 2 gene expression , promote EOS apoptosis and reduce lung tissue EOS infiltration , while reducing the expression of TGF-β1 inhibition of type III collagen deposition , mitigate and alleviate airway remodeling ; ② above the role of a dose-effect relationship , the strengthening trend with increasing dose ; ③ early intervention the case of the therapeutic effect of anti - whooping Ling capsules more significant.

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