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Angiostrongylus cantonensis (Angiostrongylus cantonensis) The Professor Chen Xintao the first time in 1935 in the heart and lung tissue of Rattus norvegicus, the pest classification on the part of round wire mesh, tube round Division, Angiostrongylus genus, is a beast of a man suffering from a parasitic disease pathogens. Adult parasites in rat pulmonary artery, the intermediate host of freshwater snails and slugs turn continued host frogs, freshwater fish, shrimp, crab, and so on. Caused by eating raw or undercooked food containing infective larvae intermediate host for transferring host and infection, or raw larvae vegetables, fruit and other contaminated food or drinking contaminated water can also be infected. Guangzhou Angiostrongylus non-suitable host, infective larvae invade the human body, in the body transitional multiple violations of the central nervous system, causing increased eosinophil meningitis or meningoencephalitis. The Angiostrongylus cantonensis endemic regions, mainly in tropical and subtropical regions in the Pacific, the Indian Ocean island countries, Southeast Asia, China, Japan and other places are outbreaks or dissemination of popular. The WTO announced 21st century emerging global threat of sexually transmitted diseases, including Guangzhou angiostrongyliasis. Angiostrongylus cantonensis in endemic regions of our country, including Guangdong, Fujian, Zhejiang, Guangxi, Hainan, Yunnan and Taiwan. From 1997 to 2007, has since 1984 reported in Guangdong Province, mainland China the first Guangzhou angiostrongyliasis, a growing trend in recent years of Angiostrongylus cantonensis number of disease, but also the distribution of an increasingly wide range in Wenzhou , Liaoning, Fujian and Beijing and has appeared in many different sizes outbreak. China's Ministry of Health in 2003 Angiostrongylus cantonensis as \Guangdong Province, Guangzhou Angiostrongylus one of the endemic areas in China in March 2007, in addition to the presence of sporadic cases, there has been a 6 human cases of small-scale outbreaks in Guangning. Angiostrongylus cantonensis epidemiological investigation has been done in parts of Guangdong before, long ago for most of the time these surveys, and there is the limitation of the scope of the investigation, the fragmented and the lack of people infected, the situation Angiostrongylus cantonensis prevention work has been difficult to adapt. In order to master Angiostrongylus epidemic status in Guangdong Province, Guangzhou, provide a scientific basis for the prevention and control of Guangzhou Angiostrongylus our group under the Joint Fund of the National Natural Science Foundation of China - Guangdong Province People's Government in 2006 to 2008 years on the west of Guangdong Province, Guangdong Province, Guangzhou Angiostrongylus prevalence survey. Objective To the west of Guangdong Province, Guangdong Province, Guangzhou Angiostrongylus definitive host rodents, intermediate host snails, as well as local residents Angiostrongylus cantonensis infection situation and characteristics, to provide a scientific basis for the prevention and control of Guangzhou Angiostrongylus. Research methods digestion check Snail intermediate host and apple snails Angiostrongylus cantonensis three larval infection; anatomical captured rodents whichever the cardiopulmonary organization check Angiostrongylus cantonensis adult; western Guangdong Jiangmen and Yangchun the two were randomly selected from a total of 600 local healthy staff survey carried infected with Angiostrongylus cantonensis Angiostrongylus cantonensis these human serum specific IgG and IgM antibodies detected by enzyme-linked immunosorbent assay method. The results of this survey inspected rodents 966, of which 541 Rattus norvegicus flavipectus 160 Amur roof rat 104 Bandicota 83, 46 Mus musculus, Rattus 15 only, smelly shrews 13 four R. confucianus. Which found that the Angiostrongylus cantonensis adult parasites positive mouse 87, the average infection rate of about 9.01%. The average positive mice infected degrees 7.45 /. Different rodent species Angiostrongylus cantonensis infection, the infection rate difference was statistically significant, which the infection rates flavipectus is 15.62% and the Rattus norvegicus infection rate was 9.61%, the infection rates of Bandicota 3.85% to 7.23% and infection rates of Amur roof rats, the Mus musculus foul shrew, Rattus and R. confucianus body are not seized Angiostrongylus cantonensis. 3. The rodent infection of different locations in western Guangdong Lianjiang infection rates up to 17.37 percent, the lowest infection rates in the Panyu district of 3.54%, 10.71%, Maoming, Jiangmen and Yangchun prevalence, 4.37% and 5.73% respectively. Significant differences in the different regions of rodents prevalence. 4. Western Guangdong inspected Snail 2217, the number of infected snails 618, the infection rate was 27.88%, the average infection 38.72 / Lo. Checked the apple snails 3723, The infected snails 242, infection rate was 6.50%, the average infection 12.01 / Lo. Snail infection with apple snails have a very significant difference. 5. The western Guangdong six different regions of two snails infection. The Snail Angiostrongylus cantonensis infection in Jiangmen of 45.00% the highest rates of infection, Yangchun region the lowest infection rate of 7.71%, Maoming, Lianjiang, Luoding, and Zhaoqing infection rates were 38.41%, 24.00%, 18.58% and 12.55%, respectively, over the infection rate there are significant differences between the Maoming 20.14% highest Yangchun region the lowest infection rate of 0.86%, Zhaoqing, Lianjiang, Jiangmen, and Luoding of infection, apple snails Angiostrongylus cantonensis infection rate of 10.79%, 8.10%, 5.13% and 2.07%, respectively, infection rates have statistically significant differences between the six regions. 6 different sizes snails infection is also different. Snail to take in all the areas surveyed 1987 2904 to distinguish between large snails and small and medium-sized snails and apple snails, compare their infection status. Snail big spiral (gt; 31g) infection rate was 22.91% (151/659), the average infection 50.94 / Lo; small and medium-sized snail (≤ 31g) infection rate was 26.28% (349/1328), the average infected with 14.12 / Lo, The large snails infected with the degree of medium and small snails 3.56 times. The the apple snails large snails (gt; 21g) infection rate was 8.26% (65/787), the average infection 20.08 / Lo; small and medium-sized snails (≤ 21g), the infection rate was 5.24% (111/2117), were infected with degrees 9.16 / Lo, large snails infected with degrees small and medium-sized snails 2.19-fold, statistically significant difference between both infection rates. 7 The survey showed: 89.83% of the respondents deny their remaining food or undercooked food whelk meat or fish, shrimp, snails, crabs, frogs History, 4.17 percent of the respondents are not sure whether their remaining food or undercooked food the food history, 6% of the respondents in their remaining food or half a lifetime consumption of fish, shrimp and history; 3.83 percent of respondents in direct or indirect contact with the labor Snail, apple snails or slugs; 66.33% of the respondents home without cutting raw food or cooked dedicated kitchenware. 8.600 serum samples to Angiostrongylus cantonensis 59 were positive for IgG antibodies, the positive rate was 9.83%. Specific IgM antibody detection in the 59 were IgG positive serum samples, the result 9 were positive for IgM antibody positive rate was 15.25%; accounted for the survey of 600 human serum samples ratio of 1.50%. 9 different survey areas, serum Angiostrongylus cantonensis detection of specific antibodies results are different. Jiangmen region serum Guangzhou Angiostrongylus specific IgG and IgM antibodies positive rate were 14.0% and 1.67%, respectively; while the the Yangchun regional human serum Guangzhou Angiostrongylus specific IgG and IgM antibody positive rate of 5.67% and 1.33%, respectively. Visible Jiangmen regional crowd cantonensis Angiostrongylus-specific antibody positive rate is higher, there are significant differences between the two groups of Angiostrongylus cantonensis IgG antibody positive rate. The findings of the conclusions with the province and China's other regions of western Guangdong rodents Guangzhou Angiostrongylus infection broadly at a medium level. Angiostrongylus infection between different species in Guangzhou there are differences, which is the most common infection of Rattus norvegicus and important; the different regional rodents in western Guangdong Guangzhou Angiostrongylus infections differences; different habitats rodents Angiostrongylus cantonensis infection. Compared with the findings of other regions in China, the west of Guangdong Province, Guangzhou, Snail Angiostrongylus infection rate in the mid to upper level, the rate of infection of apple snails in the middle level. Snail Angiostrongylus cantonensis infection than apple snails is serious, it is still at this stage west of Guangdong Province, Guangzhou Angiostrongylus natural spread of the main intermediate host. Visible at the same time: the infection rate of snails in the west of Guangdong regional differences. In addition, the different sizes of snails infection is also different, which the larger apple snails snails, its Angiostrongylus cantonensis infection rates and the higher the degree of infection; big spiral with small and medium-sized snail Snail infection rates without significantly difference, but a big spiral infection was significantly higher than the small and medium-sized snails. Angiostrongylus cantonensis in western Guangdong in different parts of the final host rodents and intermediate host snails infected basic parallel, the survey results suggest that: the distance between the South China Sea, latitude, elevation and geomorphology influence in the region Angiostrongylus nematode natural prevalence of important factors. Typically, offshore, low-latitude, low-elevation plains and hilly region hosts more serious infection. Crowd seroepidemiological survey found that a certain proportion of IgG and IgM antibodies, suggesting that: they have been or recently suffered Angiostrongylus cantonensis infection. Jiangmen crowd Angiostrongylus cantonensis-specific IgG antibodies was significantly higher than the spring region display even in different regions of the west of Guangdong Province, the chances of infection of the crowd under the influence of a variety of natural and social factors also vary. West of Guangdong Province, Guangdong Province, Guangzhou Angiostrongylus natural foci, local residents have also been infected with the threat of the pest. The survey so that we have a preliminary understanding of the prevalence and characteristics of the region Angiostrongylus cantonensis, and laid the foundation for the scientific control of Angiostrongylus cantonensis.
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